Mehmet KARACA, Hasan Altan AKKAN, İhsan KELEŞ, Dide KILIÇALP

Süksinilkolin'in köpeklerde elektrokardiyogram ve kalp atım sayısı üzerine etkisi

Süksinilkolinin 12 adet değişik yaş, cinsiyet ve ağırlıkta sağlıklı, melez köpekte elektrokardiyogram ve kalp atım sayısı üzerine etkisi araştırıldı. 0.3 mg/kg dozunda kas içi olarak uygulanan süksinilkolin etkisiyle EKG’de: (a) Bradikardi. (b) Tam kalp bloğu. (c) S-T yükselmesi. (d) T dalgası’nda pik. (e) Q-T uzaması. (f) Kardiyak arrest. (g) QRS kompleksinin amplitüdünde artış görüldü. Bir köpekte de sinüs taşikardi belirlendi. Elektrokardiyogramdaki bu değişiklikler, elektrolitlerde özellikle de potasyum seviyesinde görülen artışın ve düzensizliğin miyokardiyal hücrelerdeki fizyolojik etkileriyle açıklanabilir.

The effects of succinylcholine on electrocardiogram and heart rate in dogs

The effects of succinylcholine on the electrocardiogram and heart rate were investigated in 12 healthy cross-breed street dog in different age, sex and weights. Due to intramuscular application of succinylcholine at 0.3 mg/kg dose, changes in ECG such as; (a) Bradycardia. (b) Complete heart block. (c) S-T elevation. (d) Peaked T- wave. (e) Prolonged Q-T interval. (f) Cardiac arrest. (g) Raised QRS complex were observed. Sinus tachycardia was also determined in one dog. These ECG changes can be explained by the electrolyte disturbances especially on potassium level on myocardial cells.

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1. http://lokman.cu.edu.tr/anestezi/anestezinot/noromusk.htm
2.www.ctf.edu.tr/farma/onersuzer/pdf/tr/18_Iskelet_kasgevse ticiler.pdf
3. Taylor P (1991): The Cholinesterases. J Biol. Chem., 266: 4025-4028.
4. Durant NN, Katz RL (1982): Suxamethonium. Br. J. Anaesth., 54: 195-208.
5. Akkan HA, Gençcelep M, Karaca M, Ceylan E, Tütüncü M, Agaoglu Z, Aytekin (2004): The Effects of Succinylcholine on some Clinical, Haematological and Biochemical Parameters in Dogs. Indian Vet. J., 81: 718.
6. Edwards NJ (1987): Bolton’s Handbook of Canine and Feline Electrocardiography. 2nd ed. W.B. Saunders Company.
7. Neville IP, Graham M (2003): In vitro Succinylcholine Hydrolisis in Plasma of the African Elephant (Loxodonta africana) and Impala (Aepyceros melampus). Comp. Biochem. Physiol., 134: 123-129.
8. Al-Takrouri H, Martin TW, Mayhew JF (2004): Hyperkalemic Cardiac Arrest Following Succinylcholine Administration: The Use of Extracorporeal Membrane Oxygenation in an Emergency Situation. J Clin. Anesth., 16 (6): 449-451.
9. Huggins RM, Kennedy WK, Melroy MJ, Tollerton DG (2003): Cardiac Arrest from Succinylcholine-Induced Hyperkalemia. Am. J Health Syst Pharm., 60 (7): 694-697.
10. Markewitz BA, Elstad MR (1997): Succinylcholine-Induced Hyperkalemia Following Prolonged Pharmacologic Neuromuscular Blockade. Chest., 111 (1): 248-250.
11. Webster A, Brady W and Morris F (2002): Recognising Signs of Danger: ECG Changes Resulting from an Abnormal Serum Potassium Concentration. Emerg Med J., 19: 74-77.
12. Pick A (1966): Arrhythmias and potassium in man. Am. Heart. J., 72: 295-306.
13. Kashimoto S, Kanda F, Kumazawat T (1985): Succinylcholine-Induced Ventricular Arrhythmia during Halothane Anesthesia. Resuscitation., 12 (4): 233-239.
14. Dionisi P, Colarossi G, Bonanni M, Belomonte L, Colarossi G, Orfei P (1992): The Effects of Succinylcholine on Heart Rate and Rhythm in Infants. Minerva Anestesiol.,58 (5): 257-262.
15. Magee DA, Sweet PT, Holland AJ (1982): Cardiac Effects of Self-Taming of Succinylcholine and Repeated Succinylcholine Administration. Can. Anaesth. Soc. J., 29 (6): 577-580.
16. Fastle RK (2004): Pediatric Rapid Sequence Intubation: Incidence of Reflex Bradycardia and Effects of Pretreatment with Atropine. Pediatric Emergency Care., Oct: 651-655.
17. McAuliffe G, Bissonnette B, Boutin C (1995): Sould the Routine Use of Atropine Before Succinylcholine in Children be Reconsidered? Canadian Journal of Anaesthesia., Aug: 724-729.
18. Kleber AG (2000): ST-segment Elevation in the Electrocardiogram: A Sign of Myocardial Ischemia. Cardiovasc Res., 45: 111-118.