Bu çalışma Pentaklorofenol (PCP)'ün tavşan kanındaki antioksidan enzimler üzerine etkilerini araştırmak amacıyla düzenlenmiştir. Bu amaçla, 1200-1660 g ve yaklaşık 5-6 aylık Yeni Zelanda tavşanı kullanıldı. Glutatyon peroksidaz aktivitesinde önemli bir değişiklik olmazken, süperoksid dismutaz (SOD) aktivitesinde doza bağlı olarak % 40'a yakın inhibisyon gözlendi (P

This experiment was carried out to investigate the effect of pentachlorophenol on antioxidant enzymes of rabbits. New Zealand Rabbits, weighing 1200-1600 g and 5-6 mounts of age, were used. It was found that, although glutathion peroxidase did not change with the pentachlorophenol treatment, superoxide dismutase activity decreased (P<0.05) about 40 % dose dependently. In addition, pentachlorophenol treatment increased both plasma creatine and lactat dehydrogenase activities significantly (P<0.05). It was concluded that the cancerogenic effect of pentachlorophenol may be due to the inhibition of superoxide dismutase activity or/and increase in the hydroxyl radical activity. More studies are needed to prove our hypothesis.