Aykut BUĞRA ŞENTÜRK, Basri ÇAKIROĞLU, Ersan ARDA

Mikroskopik varikoselektominin infertil erkeklerin gonadal hormonlar ve semen parametreleri üzerine etkisi

Amaç: İnfertilite kliniğine başvuran infertil erkeklere uygulanan, subinguinal mikro varikoselektominin, cinsiyet hormonları üzerindeki etkisini değerlendirmek.Yöntem: Ocak 2014 ile Haziran 2016 tarihleri arasında, en az bir yıldır korunmasız cinsel ilişkiye rağmen, hiç çocuğu olmayan, birincil infertil hastalar çalışmaya dahil edildi. Çalışma kriterlerine uyan, 76 hastanın, fo- likül uyarıcı hormon, luteinize edici hormon, total testosteron düzeyleri, semen analizi ve skrotal Doppler ultrasonografi sonuçları retrospektif olarak değerlendirildi.Bulgular: Ortalama infertilite süresi 3.6 yıldı (1.5-6.3). Ameliyattan önce ve altı ay sonraki toplam testosteron değerleri sırasıyla 380 (340-465) ve 385 (350-470) idi. Bu istatistiksel olarak anlamlıydı (p <0.001). Bu artış, LH düzeylerinin 6.59 ± 1.37’den 6.79 ± 0.94’e çıkması ile koreleydi ve bu da istatistiksel olarak anlamlı bulundu (p <0,019).Sonuç: İnfertilite ve varikosel genellikle ağrı ve infertilite açısından değerlendirilmekle birlikte, cerrahi sonrası serum testosteron düzeylerinde anlamlı bir artış olması nedeniyle, düşük serum testosteron düzeyi olan hastaların ayırıcı tanısında varikosel düşünülmelidir.

Anahtar Kelimeler:

Kısırlık, testosteron, Varikosel

Effect of microscopic varicocelectomy on gonadal hormones and semen parameters in infertile males

Objective: To evaluate the effect of subinguinal micro varicocelectomy on sex hormones of infertile males who are consulting infertility clinic.Methods: Between the dates of January 2014 to June 2016, despite at least one year of unprotected sexual intercourse, having no children, primarily infertile patients were included in the study. Follicle stimulating hormone, luteinizing hormone, total testosterone levels, semen analysis and scrotal Doppler ultrasonography results in a total of 76 patients, who fulfilled the study criteria were reevaluated retrospectively.Results: Average time of infertility was 3.6 years (1.5-6.3). Total testosterone values before and six months after surgery were 380( 340-465) and 385(350-470) respectively. This was statistically significant (p <0.001). This increase was correlated with an increase of the LH levels from 6.59±1.37 to 6.79±0.94 and this was also seen as statistically significant (p<0.019).Conclusion: Although infertility and varicocele is generally considered to be evaluated in terms of pain and infertility, due to a significant increase of serum testosterone levels after surgery, varicocele should be consi- dered in the differential diagnosis of patients with low serum testosterone levels.

Keywords:

varicocele, infertility, testosterone,

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