Ali Rıza TÜRKOĞLU, Yasemin ÜSTÜNDAĞ, Soner ÇOBAN, Muhammet GÜZELSOY, Murat ÖZTÜRK, Atilla SATIR, Hakan DEMİRCİ, Kağan HUYSAL

Mesane Tümörlerinde Hemoglobin-Redcell Distrubition Width Oranı (Hb/RDW) ve Neutrophil- Lymphocyte Oranı (NLR) Lamina Propria İnvazyonunu Tahmin Etmede Kullanılabilir mi?

Amaç: Non-musculer invazive bladder cancer (NMIBC) hastalarında Hemoglobin-Red cell Distrubition Width oranı (Hb/RDW) ve Nötrofil/Lenfosit oranının (NLR) mesanenin transüretral rezeksiyonu öncesi lamina propria invazyonunu önğörmede önemini araştırmak.Materyal–methods: Ocak 2010- Haziran 2016 yılları arası mesanenin transüretral rezeksiyonu sonrası patolojisi NMIBC olan hastaların verileri retrospektif değerlendirildi. Hastalar Grup 1: Ta (mukoza tutulumu), Grup 2: T1 (submukoza tutulumu) olarak 2 gruba ayrıldılar. Hastaların yaşları, cinsiyetleri, tümör boyutu ve tümör sayıları belirlendi. Preoperatif tam kan değerlerinden lökosit (WBC), hemoglobin (Hb), nötrofil (N), lenfosit (L), monosit (M), platelet (PLT), mean platelet volümü (MPV), Red cell Distrubition Width (RDW) değerleri belirlendikten sonra NLR, PLR, LMR değerleri hesaplandı. Hb/RDW oranı belirlendi.Bulgular: Patolojik evresi NMIBC olan 369 hasta değerlendirildi. Gruplar arasında yaş farkı yoktu. Grup 1 (Ta); 219 hasta, 66.3±10.7 yıl olup grup 2 (T1); 150 hasta, 66.9±10.4 yıl oldu (p=0.638). NLR grup 2’de grup 1’den yüksek olup (sırasıyla 2.4 (1.5), 2.2 (1.5) ve p=0.042 ) istatistiksel olarak bu yükseklik anlamlıdır. Gruplar arasında Hb ve RDW oranları bakımından farklılık izlenmemesine rağmen Hb/RDW oranı grup 2’de grup 1’den düşüktür (sırasıyla 0.89±21, 0.94±19 ve p=0.019) ve istatistiksel olarak bu azalma anlamlıdır. Sonuç: Preoperatif dönemde periferik kandan kolay yolla elde edilebilen Hb/RDW oranında azalma ve NLR yükselmenin lamina propria invazyonu (T1) ile ilişkili olabileceğini düşünmekteyiz. Bu çalışmaların prospektif geniş serili çalışmalarla desteklenmesi gerekir.

Anahtar Kelimeler:

kasa invaze olmayan mesane kanseri, hemoglobin-red cell distrubition oranı, nötrofil-lenfosit oranı, lamina propria invazyonu

The Hemoglobin-Red Cell Distribution Width and Neutrophil -Lymphocyte Ratio in Predicting Lamina Propria Invasion in Bladder Tumors?

Purpose: To investigate the importance of the Hemoglobin/Red cell distribution width ratio (Hb/RDW) and Neutrophil/Lymphocyte ratio (NLR) in predicting bladder lamina propria invasion before transurethral resection in non-muscular invasive bladder cancer (NMIBC) patientsMethods: The data of the patients whose pathology after transurethral resection of the bladder was NMIBC between January 2010 and June 2016 were evaluated retrospectively. Group 1 had Ta (mucosa involvement) and Group 2 had T1 (submucosa involvement) lesions. The age, gender, tumor size and number of tumors of the patients were identified. The preoperative blood leucocyte (WBC), hemoglobin (Hb), neutrophil (N), lymphocyte (L), monocyte (M), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW) values were identified and the NLR, PLR, LMR values calculated. The Hb/RDW ratio was determined. Results: A total of 369 patients were evaluated. The mean age was similar between groups. Group 1 (Ta) consisted of 219 patients (66.3±10.7 years) and Group 2 (T1) 150 patients (66.9±10.4 years) (p=0.638). NLR was higher in Group 2 than Group 1 (2.4 (1.5) and 2.2 (1.5), respectively, p=0.042) and this difference was statistically significant. The Hb/RDW ratio in Group 2 was lower than in Group 1 (0.89±21 and 0.94±19, respectively, p=0.019) and this difference was statistically significant. Conclusion: We believe that a decrease in the Hb/RDW ratio and increase in NLR, which can be easily determined from the peripheral blood in the preoperative period, can be associated with lamina propria invasion (T1). These studies should be supported with prospective large series.

Keywords:

Non-muscular invasive bladder cancer, Hemoglobin-red cell distribution width ratio, Neutrophil-lymphocyte ratio, Lamina propria invasion.,

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