The effects of long-term administration of ethyl alcohol on insulin and glucagon hormone levels during pregnancy and lactation periods of rats were investigated. Female wistar albinos, 200±20 g, were used in this study. The control group consisted of 15 rats, and the experimental group consist of 25 ethyl-alcohol-addicted rats. While 0.9% saline (with sucrose) was to the control group, a 5 g kg perday dose of 20% ethyl alcohol was given to the experimental group. Blood samples were taken five times, during the pre-pregnancy (1), pregnancy (3), lactation (1) periods. Insulin and glucagon levels of sera were measured by RIA method. Insulin hormone levels increased until the 3rd trimester in the control group and decreased during subsequent periods. Similar results were observed in the experimental group but levels in the experimental group in the pre-pregnancy period were lower than those in the control group, and in the pregnancy phase they were higher (p