Right ventricular function and its relation with TIMI frame count in the coronary slow flow phenomenon

To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P = 0.05, P = 0.002, respectively). Late diastolic velocity (16.4 ± 3 cm/s, 14.4 ± 3 cm/s) and isovolumetric relaxation time (80 ± 9 ms, 66 ± 4 ms) were significantly higher in the patient group than in the controls (P = 0.024, P < 0.001, respectively). Right ventricular myocardial performance index was significantly prolonged in the coronary slow flow group (0.51 ± 0.03, 0.40 ± 0.02, P < 0.001). TIMI frame count was negatively correlated with the tricuspid lateral annulus early diastolic velocity and the ratio of tricuspid lateral annulus early to late diastolic velocity, whereas it was positively correlated with tricuspid isovolumetric relaxation time and right ventricular myocardial performance index. Conclusion: Right ventricular diastolic dysfunction exists in patients with the coronary slow flow phenomenon and it is correlated with TIMI frame count.

Right ventricular function and its relation with TIMI frame count in the coronary slow flow phenomenon

To investigate right ventricular function using conventional and tissue Doppler echocardiography in patients with coronary slow flow. Materials and methods: Twenty-two patients with slow coronary flow and 22 healthy subjects were included in the study. Right ventricular function was evaluated by conventional and tissue Doppler echocardiography. Additionally, right ventricular global function was assessed by myocardial performance index. Results: The tricuspid annulus peak early diastolic velocity (11.4 ± 2.2 cm/s, 13.9 ± 3 cm/s) and ratio of early to late diastolic velocity (0.70 ± 0.17 cm/s, 1.2 ± 0.38 cm/s) were lower in the patient group than in the controls (P = 0.05, P = 0.002, respectively). Late diastolic velocity (16.4 ± 3 cm/s, 14.4 ± 3 cm/s) and isovolumetric relaxation time (80 ± 9 ms, 66 ± 4 ms) were significantly higher in the patient group than in the controls (P = 0.024, P < 0.001, respectively). Right ventricular myocardial performance index was significantly prolonged in the coronary slow flow group (0.51 ± 0.03, 0.40 ± 0.02, P < 0.001). TIMI frame count was negatively correlated with the tricuspid lateral annulus early diastolic velocity and the ratio of tricuspid lateral annulus early to late diastolic velocity, whereas it was positively correlated with tricuspid isovolumetric relaxation time and right ventricular myocardial performance index. Conclusion: Right ventricular diastolic dysfunction exists in patients with the coronary slow flow phenomenon and it is correlated with TIMI frame count.

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  • Beltrame JF, Limaye SB, Wuttke RD, Horowitz JD. Coronary hemodynamic and metabolic studies of the coronary slow phenomenon. Am Heart J 2003; 146: 84–90.
  • Hawkins BM, Stavrakis S, Rousan TA, Abu-Fadel M, Schechter E. Coronary slow flow—prevalence and clinical correlations. Circ J 2012; 76: 936–42.
  • Mangieri E, Macchiarelli G, Ciavolella M, Barilla F, Avella A, Martinotti A et al. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn 1996; 37: 375–81.
  • Cin VG, Pekdemir H, Camsar A, Çiçek D, Akkuş MN, Parmaksız T et al. Diffuse intimal thickening of coronary arteries in slow coronary flow. Jpn Heart J 2003; 44: 907–19. Sezgin AT, Sigirci A, Barutçu I, Topal E, Sezgin N, Özdemir R et al. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 2003; 14: 155–61.
  • Baykan M, Baykan EC, Turan S, Gedikli O, Kaplan S, Kiriş A et al. Assessment of left ventricular function and Tei index by tissue Doppler imaging in patients with slow coronary flow. Echocardiography 2009; 26: 1167–72.
  • Elsherbiny IA. Left ventricular function and exercise capacity in patients with slow coronary flow. Echocardiography 2012; 29: 158–64.
  • Nurkalem Z, Gorgulu S, Uslu N, Orhan AL, Alper AT, Erer B et al. Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow. Int J Catdiovasc Imaging 2009; 25: 25–32.
  • Dell’Italia LJ. Reperfusion for right ventricular infarction. N Engl J Med 1998; 338: 978–980.
  • Ulusoy RE, Yokusoglu M, Baysan O, Kırılmaz A, Kılıçaslan F, Cebeci BS. Ventricular functions, aortic elastic properties, and endothelial functions in patients with hypertensive response to treadmill exercise testing. Turk J Med Sci 2011; 41: 781–787. Çiçekçioğlu H, Ergün İ, Uçar Ö, Yüksel C, Azak A, Abaylı E et al. Cardiac complications of secondary hyperparathyroidism in chronic hemodialysis patients. Turk J Med Sci 2011; 41: 789–794.
  • Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996; 93: 879–88. Kopetz VA, Penno MA, Hoffmann P, Wilson DP, Beltrame JF. Potential mechanisms of the acute coronary syndrome presentation in patients with the coronary slow flow phenomenon—insight from a plasma proteomic approach. Int J Cardiol 2012; 156: 84–91.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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