Ali Muhtar TİFTİK, Levent SARIYILDIZ, Turan AKDAĞ

Kriptorşit, oligospermi ve varikoselli hastalarda anti-müllerian hormon (AMH) ve farklı biyokimyasal parametrelerin karşılaştırılması

Amaç: Kriptorşit, oligospermi ve varikosel tanılı hastalarda AMH ve farklı biyokimyasal parametrelerin kıyaslanmasıyoluyla değişimin saptanması.Yöntem ve gereç: Çalışmaya 18-24 yaş arası varikosel (n = 20), oligospermi (n = 20) ile 8-12 yaş arası kriptorşit (n = 20)hasta grupları; 8-12 yaş arası (n = 20) ve 18-24 yaş arası (n = 20) sağlıklı bireyler kontrol gruplar olarak alındı. Hasta vekontrol gruplarından kan örnekleri alınarak AMH, testosteron, FSH, LH, ve prolaktin parametreleri çalışıldı.Bulgular:Çalışmada pubertal dönemde (8-12 yaş arası) 20 kriptorşitli çocuk ile 20 normal çocuk AMH değerleri sırasıyla 73,04± 44,5 ng/mL ve 84,81 ± 59,1 ng/mL olarak bulunurken (P = 0,56) postpubertal dönemde (18-24 yaşarası) 20 oligospermilihasta ile 20 normal birey AMH değerleri sırasıyla 5,19 ± 4,9 ng/mL ve 7,66 ± 5,6 ng/mL (P = 0,10) ve 20 varikoselli hasta ile 20normal birey AMH değerleri ise sırasıyla 7,15 ± 5,8 ng/mL ve 7,66 ± 5,6 ng/mL (P = 0,82) olarak saptandı.Sonuç: AMH düzeylerinin belirlenmesine yönelik daha geniş katılımcı ile yapılacak yeni çalışmalarla varikosel, oligospermive kriptorşidik vakalarda serum AMH ölçümünün tanı kriteri olabileceği düşünülmektedir.

Anahtar Kelimeler:

Anti-Müllerian hormon, varikosel, infertilite, kriptorşidizm

A comparative investigation of anti-Müllerian hormone (AMH) and various biochemical parameters in patients with cryptorchidism, oligospermia, or varicocele*

To investigate the serum AMH and various biochemical parameter levels in patients with cryptorchidism, oligospermia, or varicocele. Materials and methods: This study included 100 participants, divided into 5 groups: cryptorchidism (n = 20), varicocele (n = 20), oligospermia (n = 20), and 2 control groups [control 1, 8-12 years old (n = 20) and control 2, 18-24 years old (n= 20)]. Using the blood samples drawn from both patient and control groups, AMH, testosterone, FSH, LH, and prolactin parameters were investigated. Results: AMH values measured were found to be 73.04 ± 44.5 ng/mL and 84.81 ± 59.1 ng/mL in 20 children with cryptorchidism and 20 healthy children (both groups aged between 8 and 12 years), respectively (P = 0.56). In the present study, AMH values were found to be 5.19 ± 4.9 ng/mL and 7.66 ± 5.6 ng/mL in 20 patients with oligospermia and 20 healthy individuals (both groups aged between 18 and 24 years), respectively (P = 0.10). AMH values in 20 patients with varicocele and 20 healthy controls aged between 18 and 24 years were determined to be 7.15 ± 5.8 ng/mL and 7.66 ± 5.6 ng/mL, respectively (P = 0.82). No significant P values were determined, but the decrease in values was remarkable. Conclusion: New studies with larger number of participants are needed in order to determinate AMH levels in patients with varicocele, cryptorchidism, or varicocele for diagnostic criteria.

Keywords:

varicocele, infertility, cryptorchidism, Anti-Müllerian hormone,

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