Talat KILIÇ, Sadık SÖĞÜT, Zeki YILDIRIM, Nurhan KÖKSAL

Increased nitrite levels in exhaled breath condensate in asthmalike syndrome induced by occupational sulfur dioxide exposure

Amaç: Bu çalışmanın amacı bu işçilerde yoğunlaşmış ekspirum havasında (YEH) nitrit seviyesinin artıp artmadığını araştırmaktır. Yöntem ve gereç: Çalışmaya 25i sigara içenlerden olmak üzere 48 gönüllü ABSu olan işçi ve benzer yaş ve cinsiyetten 23ü sigara içenlerden olmak üzere 45 sağlıklı gönüllü alındı. İşçilerin SO2 maruziyeti öncesi ve sonrasında elde edilen YEHde nitrit düzeyleri ölçüldü ve sağlıklı kişilerinki ile karşılaştırıldı. Bulgular: ABSli işçilerin YEHde ölçülen bazal nitrit düzeyleri (19,31 ± 1,06 nmol/mL) sağlıklı gönüllülerin nitrit düzeylerinden (13,08 ± 1,36 nmol/mL, P < 0,001) anlamlı yüksek bulundu. Akut SO2 maruziyeti nitrit düzeylerini bazal düzeye göre anlamlı olarak yükseltti (23,62 ± 1,36, P < 0,05). Sigara içen ve içmeyenlerin SO2 maruziyeti öncesi nitrit düzeyleri benzer olarak bulundu (17,85 ± 1,72 ve 20,20 ± 1,59, P > 0,05). Sonuç: Bu çalışmada tarım iş kolunda kayısı kükürtleme işlemi sırasında SO2 maruziyeti sonucu oluşan ABSli işçilerin YEH nitrit düzeylerinin arttığı gösterildi. Bu artış bu sendromun patogenezinde inflamasyonun olabileceğini düşündürmektedir. Bu çalışma tarım iş kolunda yapılan ilk çalışmadır ve bu yöntemin alan çalışmalarında uygun olabileceğini göstermektedir.

Mesleki kükürt dioksit maruziyetine bağlı astım benzeri sendromunda yoğunlaşmış ekspirium havasında nitrik oksit düzeyinin artması

Aim: To investigate whether nitrite levels were abnormally high in expired breath condensate (EBC) from workers with asthma-like syndrome. Materials and methods: We measured the nitrite levels in EBC from 48 volunteer workers, including 25 smokers, with asthma-like syndrome before and after SO2 exposure and compared these levels with those from 44 nonexposed control subjects, including 23 smokers. Results: Baseline concentrations of nitrite in the workers before SO2 exposure were higher (19.31 ± 1.06 nmol/mL) than in the controls (13.08 ± 1.36 nmol/mL; P < 0.001). Acute SO2 exposure produced a significant increase in concentrations of nitrite (23.62 ± 1.36) compared to the baseline value (P < 0.05). Preexposure nitrite concentrations were similar in smoking and nonsmoking workers (17.85 ± 1.72 and 20.20 ± 1.59; P > 0.05). Conclusion: We concluded that nitrite levels in EBC are increased in the asthma-like syndrome induced by occupational SO2 exposure in an agricultural environment, suggesting the role of infl ammation in the syndrome; this first application of the EBC method may be suitable in other field studies in occupational medicine.

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