Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

To evaluate vitamin D levels and risk factors for vitamin D deficiency in healthy newborns and their mothers. Materials and methods: Ninety-nine healthy pregnant women (≥37 weeks of gestation) were enrolled in the study. Previous history of pregnancies and births, nutritional status, multivitamin supplementation, educational status, type of clothing, and the economic level of the family were recorded. Blood samples were drawn from the mothers and the umbilical cord of the newborns to measure serum 25(OH)D3, calcium, phosphorus, and parathormone levels. Results: While vitamin D insufficiency was identified as 62.6% in mothers, it was 58.6% in newborns; on the other hand, the incidence of vitamin D deficiency was 18.2% and 15.2% in mothers and newborns, respectively. Maternal serum 25(OH)D3 concentrations were not significantly related to the number of pregnancies or births, type of clothing, or the nutritional, economical, or educational status of the family (P > 0.05). Conclusion: These findings suggest that despite a sunny environment, maternal vitamin D deficiency and insufficiency are still important health problems in a developed region of Turkey. Therefore, more effective vitamin D prophylaxis programs are required to prevent vitamin D deficiency in pregnant women and their offspring.

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

To evaluate vitamin D levels and risk factors for vitamin D deficiency in healthy newborns and their mothers. Materials and methods: Ninety-nine healthy pregnant women (≥37 weeks of gestation) were enrolled in the study. Previous history of pregnancies and births, nutritional status, multivitamin supplementation, educational status, type of clothing, and the economic level of the family were recorded. Blood samples were drawn from the mothers and the umbilical cord of the newborns to measure serum 25(OH)D3, calcium, phosphorus, and parathormone levels. Results: While vitamin D insufficiency was identified as 62.6% in mothers, it was 58.6% in newborns; on the other hand, the incidence of vitamin D deficiency was 18.2% and 15.2% in mothers and newborns, respectively. Maternal serum 25(OH)D3 concentrations were not significantly related to the number of pregnancies or births, type of clothing, or the nutritional, economical, or educational status of the family (P > 0.05). Conclusion: These findings suggest that despite a sunny environment, maternal vitamin D deficiency and insufficiency are still important health problems in a developed region of Turkey. Therefore, more effective vitamin D prophylaxis programs are required to prevent vitamin D deficiency in pregnant women and their offspring.

___

  • Ahmed I, Atiq M, Iqbal J, Khurshid M, Whittaker P. Vitamin D deficiency rickets in breast-fed infants presenting with hypocalcaemic seizures. Acta Paediatr 1995; 84: 941–942.
  • Camadoo L, Tibbott R, Isaza F. Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions. Nutr J 2007; 6: 23.
  • Wei SQ, Audibert F, Hidiroglou N, Sarafin K, Julien P, Wu Y, Luo ZC, Fraser WD. Longitudinal vitamin D status in pregnancy and the risk of pre-eclampsia. BJOG 2012; 119: 832–839.
  • Wei SQ, Qi HP, Luo ZC, Fraser WD. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013: 26; 889–899.
  • Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, Williams MA. Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 2008; 3: e3753.
  • Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 2007; 120: 1031– 10
  • Morales E, Guxens M, Llop S, Rodriguez-Bernal CL, Tardon A, Riaño I, Ibarluzea J, Lertxundi N, Espada M, Rodriguez A et al. Circulating 25-hydroxyvitamin D3 in pregnancy and infant neuropsychological development. Pediatrics 2012; 130: e913– e9
  • Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C; Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 2008; 62: 68–77.
  • Orbak Z, Karacan M, Doneray H, Karakelleoglu C. Congenital rickets presenting with hypocalcaemic seizures. West Indian Med J 2007; 56: 364–367.
  • O’Riordan MN, Kiely M, Higgins JR, Cashman KD. Prevalence of suboptimal vitamin D status during pregnancy. Ir Med J 2008; 101: 242–243.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911–1930.
  • Pehlivan İ, Hatun Ş, Aydoğan M, Babaoğlu K, Gökalp AS. Maternal vitamin D deficiency and vitamin D supplementation in healthy infants. Turk J Pediatr 2003; 45: 315–320.
  • Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122: 398–417.
  • Ergür AT, Berberoğlu M, Atasay B, Şıklar Z, Bilir P, Arsan S, Söylemez F, Öcal G. Vitamin D deficiency in Turkish mothers and their neonates and in women of reproductive age. J Clin Res Pediatr Endocrinol 2009; 1: 266–269.
  • Kovacs CS. Maternal vitamin D deficiency: fetal and neonatal implications. Semin Fetal Neonatal Med 2013; doi: 10.1016/j. siny.2013.01.005 (Epub ahead of print).
  • Bassir M, Laborie S, Lapillonne A, Claris O, Chappuis MC, Salle BL. Vitamin D deficiency in Iranian mothers and their neonates: a pilot study. Acta Paediatr 2001; 90: 577–579.
  • Dawodu A, Wagner CL. Mother-child vitamin D deficiency: an international perspective. Arch Dis Child 2007; 92: 737–740.
  • Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr 2005; 81: 1060–1064. van der Meer IM, Karamali NS, Boeke AJ, Lips P, Middelkoop BJ, Verhoeven I, Wuister JD. High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands. Am J Clin Nutr 2006; 84: 350–353.
  • Andiran N, Yordam N, Ozon A. Risk factors for vitamin D deficiency in breast-fed newborns and their mothers. Nutrition 2002; 18: 47–50.
  • Halicioglu O, Aksit S, Koc F, Akman SA, Albudak E, Yaprak I, Coker I, Colak A, Ozturk C, Gulec ES. Vitamin D deficiency in pregnant women and their neonates in spring time in western Turkey. Paediatr Perinat Epidemiol 2012; 26: 53–60.
  • Thandrayen K, Pettifor JM. Maternal vitamin D status: implications for the development of infantile nutritional rickets. Endocrinol Metab Clin North Am 2010; 39: 303–320.
  • Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol 2011; 7: 337–345.
  • Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–2357.
  • Abrams SA. In utero physiology: role in nutrient delivery and fetal development for calcium, phosphorus, and vitamin D. Am J Clin Nutr 2007; 85: 604S–607S.
  • McCullough ML. Vitamin D deficiency in pregnancy: bringing the issues to light. J Nutr 2007; 137: 305–306.
  • Josefson JL, Feinglass J, Rademaker AW, Metzger BE, Zeiss DM, Price HE, Langman CB. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency. J Clin Endocrinol Metab 2013; 98: 114–119.
  • Specker BL. Does vitamin D during pregnancy impact offspring growth and bone? Proc Nutr Soc 2012; 71: 38–45.
  • Cianferotti L, Marcocci C. Subclinical vitamin D deficiency. Best Pract Res Clin Endocrinol Metab 2012; 26: 523–537.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Asymmetric dimethyl arginine levels in chronic hemodialysis patients

Aydın ÇİFCİ, Salih İNAL, Coşkun KAYA

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

Gökçe GÜR, Ayhan ABACI, Adem Yasin KÖKSOY, Ahmet ANIK, Gönül ÇATLI

Evaluation of histopathologic and histomorphometric changes of testicular tissue and gonadotropin levels following consumption of methylphenidate in male mice

Simin FAZELIPOUR, Zahra TOOTIAN, Zahra GHAHRI SAREMI, Minoo SHAFII, Mohammad Taghi SHEIBANI, Seyed Babak KIAEI, Mehrnush KIUMARSI, Fardin ASSADI

The effect of lycopene on the ototoxicity induced by cisplatin

Mehmet Turan ÇİÇEK, Mahmut Tayyar KALCIOĞLU, Tuba BAYINDIR, Yüksel TOPLU, Mustafa IRAZ

Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation

Bekir Suat KÜRKÇÜOĞLU, Melehat DÖNMEZ, Seher ALTINEL, Seda Banu AKINCI

Early graft dysfunction and mortality rate in marginal donor liver transplantation

Pınar SARKUT, Barış GÜLCÜ, Remzi İŞÇİMEN, Murat KIYICI, Gürkan TÜRKER

The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

Özlem ŞENGÜL, Dilek UYGUR, Mustafa GÜLEÇ, Berna DİLBAZ, Esma Meltem ŞİMŞEK, Ümit GÖKTOLGA

Comparison in clinical features and life impact between juvenile-onset and adult-onset ankylosing spondylitis

Mingqiang GUAN, Jian WANG, Zhigang ZHU, Jun XIAO, Liang ZHAO, Zhihan LI, Zhanjun SHI

Effect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological study

Zeynep AKTÜRK, Ersan ODACI, Ayşe İKİNCİ, Orhan BAŞ, Sinan CANPOLAT

The effect of lycopene on the ototoxicity induced by cisplatin*

Tuba BAYINDIR, Mahmut Tayyar KALCIOĞLU, Mehmet Turan ÇİÇEK, Mustafa IRAZ, Yüksel TOPLU