Gülden BİLGİN, Çiğdem ATAMAN HATİPOGLU, Şerife ALTUN, Cemal BULUT, Sami KINIKLI, Ali Pekcan DEMİRÖZ

An investigation of pulmonary findings of Crimean-Congo haemorrhagic fever patients

Crimean-Congo haemorrhagic fever (CCHF) generally affects many organs. In this study a retrospective evaluation of the pulmonary findings of CCHF patients was made. Materials and methods: The records of patients were retrospectively analysed. For each patient an evaluation was made of age, sex, occupation, place of residence, contact with ticks, smoking history, and pulmonary radiological and laboratory findings. A confirmed diagnosis of CCHF was made on determination by enzyme-linked immunosorbent assay or polymerase chain reaction. Results: Of the 128 patients, 48.4% were female. Symptoms of coughing were determined in 18% of patients, sputum in 4.7%, chest pain in 3.9%, dyspnoea in 3.1%, and haemoptysis in 0.8%. The mortality rate was 7%. In terms of sex, place of residence, contact with ticks, smoking, findings of the respiratory system, and physical examination findings, no statistically significant difference was seen between the survivor and nonsurvivor groups (P > 0.05). The white blood cell count values of the survivors were determined to be significantly lower compared to those of the nonsurvivors and the alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatine phosphokinase, and C-reactive protein values of the nonsurvivors were significantly higher compared to those of the survivors (P < 0.05). Conclusion: CCHF can be fatal for the respiratory system. An early diagnosis of CCHF and referral to a specialised centre is therefore important.

Anahtar Kelimeler:

Key words: Crimean-Congo haemorrhagic fever, lung, pulmonary radiograph

An investigation of pulmonary findings of Crimean-Congo haemorrhagic fever patients

Keywords:

Key words: Crimean-Congo haemorrhagic fever, lung, pulmonary radiograph,

PDF

___

Örmen B, Türker N, Ural S, El S, Kaptan F, Vardar Ç, Coşkun NA. Five cases of Crimean-Congo haemorrhagic fever from Western Anatolia, Turkey. Klimik J 2010; 23: 116–9 (in Turkish with English abstract).
Kara A. Crimean–Congo haemorrhagic fever. Turk Pediatr J 2006; 49: 175–84.
Ergönül ö. Crimean-Congo haemorrhagic fever (CCHF) in Turkey: a zoonosis which can cause nosocomial infection: invited commentary. Turkiye Klinikleri J Med Sci 2008; 28: 677–
Wolfel R, Paweska JT, Petersen N, Grobbelaar AA, Leman PA, Hewson R, Georges-Courbot MC, Papa A, Günther S, Drosten C. Virus detection and monitoring of viral load in CrimeanCongo haemorrhagic fever virus patients. Emerg Infect Dis 2007; 13: 1097–100.
Öztürk Engin D, Şengöz İnan A, Erdem İ, Ceran N, Altınaş J, Özyürek S, Karagül E, Göktaş P. Crimean-Congo haemorrhagic fever: evaluation of eight cases. Turk J Infection 2009; 23: 105–
Whitehouse CA. Crimean-Congo haemorrhagic fever. Antiviral Res 2004; 64: 145–60.
Sumer A. The evaluation of the patients who were admitted to the emergency department of Kaş State Hospital because of tick biting. Kafkas Üniv Vet Fak Derg 2010; 16: 49–53 (in Turkish with English abstract).
Kartı SS. Crimean-Congo haemorrhagic fever. Proceedings of the National Congress of Haematology, Antalya; 2009: 109–14 (in Turkish).
Bakir M, Ugurlu M, Dokuzoguz B, Bodur H, Tasyaran MA, Vahaboglu H. Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures. J Med Microbiol 2005; 54: 385–9. Yilmaz GR, Buzgan T, Torunoglu MA, Safran A, Irmak H, Com S, Uyar Y, Carhan A, Ozkaya E, Ertek M. A preliminary report on Crimean-Congo haemorrhagic fever in Turkey. Eurosurveillance 2008; 13: 18953.
Gunes T, Engin A, Poyraz O, Elaldi N, Kaya S, Dokmetas I, Bakir M, Cinar Z. Crimean-Congo haemorrhagic fever virus in high-risk population, Turkey. Emerg Infect Dis 2009; 15: 461–
Maltezou HC, Andonova L, Andraghetti R, Bouloy M, Ergonul O, Jongejan F, Kalvatchev N, Nichol S, Nisdrig M, Platonov A et al. Crimean-Congo haemorrhagic fever in Europe: current situation calls for preparedness. Eurosurveillance 2010; 15: 1950
Swanepoel R, Gill DE, Shepherd AJ, Leman PA, Mynhardt JH, Harvey S. The clinical pathology of Crimean-Congo haemorrhagic fever. Clin Infect Dis 1989; 11: 794–800. Çilingiroğlu N, Temel F, Altıntaş H. Public’s knowledge, opinions and behaviors about Crimean-Congo haemorrhagic fever: an example from Turkey. Kafkas Üniv Vet Fak Derg 2010; 16: 17–22.