Emine ŞEN, Kadriye Ufuk ELGİN, Pınar YÜKSEKKAYA, Mehmet Hakan TIRHIŞ

Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population

To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects. Materials and methods: There were 404 healthy subjects included prospectively in this study. The subjects were divided into 3 groups (Group 1: 93 subjects aged 60). Corneal compensated IOP (IOPcc), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer. Results: When all the study groups were evaluated, a moderately significant negative correlation was found between age and CH and between age and CRF (Spearman's rho = -0.372 and -0.353, respectively; P < 0.0001 for both correlations). There were significant age-related differences among the 3 groups in terms of IOPg, CH, CRF, and central corneal thickness (P = 0.002, P = 0.000, P = 0.000, P = 0.006). There was no confirmation of any difference of IOPcc among the groups (P = 0.427). Conclusion: The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.

Anahtar Kelimeler:

Key words: Corneal biomechanics, corneal hysteresis, corneal resistance factor, intraocular pressure, ocular response analyzer

Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population

Keywords:

Key words: Corneal biomechanics, corneal hysteresis, corneal resistance factor, intraocular pressure, ocular response analyzer,

PDF

___

Kamiya K, Shimizu K, Ohmoto F. Effect of aging on corneal biomechanical parameters using the ocular response analyzer. J Refract Surg 2009; 25: 888–893.
Kamiya K, Hagishima M, Fujimura F, Shimizu K. Factors affecting corneal hysteresis in normal eyes. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1491–1494.
Kirwan C, O’Keefe M, Lanigan B. Corneal hysteresis and intraocular pressure measurement in children using the Reichert ocular response analyzer. Am J Ophthalmol 2006; 142: 990–992.
Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N. Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients. Invest Ophthalmol Vis Sci 2008; 49: 3262–3268.
Shen M, Fan F, Xue A, Wang J, Zhou X, Lu F. Biomechanical properties of the cornea in high myopia. Vision Res 2008; 48: 2167–2171.
Ortiz D, Piñero D, Shabayek MH, Arnalich-Montiel F, Alió JL. Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and keratoconic eyes. J Cataract Refract Surg 2007; 33: 1371–1375.
Foster PJ, Baasanhu J, Alsbirk PH, Munkhbayar D, Uranchimeg D, Johnson GJ. Central corneal thickness and intraocular pressure in a Mongolian population. Ophthalmology 1998; 105: 969–973.
Eysteinsson T, Jonasson F, Sasaki H, Arnarson A, Sverrison T, Sasaki K; Reykjavik Eye Study Group. Central corneal thickness, radius of the corneal curvature and intraocular pressure in normal subjects using non-contact techniques: Reykjavik Eye Study. Acta Ophthalmol Scand 2002; 80: 11–15.
Hahn S, Azen S, Ying-Lai M, Varma R; Los Angeles Latino Eye Study Group. Central corneal thickness in Latinos. Invest Ophthalmol Vis Sci 2003; 44: 1508–1512.
Siu A, Herse P. The effect of age on human corneal thickness. Statistical implications of power analysis. Acta Ophthalmol (Copenh) 1993; 71: 51–56.
Khoramnia R, Rabsilber TM, Auffarth GU. Central and peripheral pachymetry measurements according to age using the Pentacam rotating Scheimpflug camera. J Cataract Refract Surg 2007; 33: 830–836.
Niederer RL, Perumal D, Sherwin T, McGhee CN. Age-related differences in the normal human cornea: a laser scanning in vivo confocal microscopy study. Br J Ophthalmol 2007; 91: 1165–1169.
Altinok A, Sen E, Yazici A, Aksakal FN, Oncul H, Koklu G. Factors influencing central corneal thickness in a Turkish population. Curr Eye Res 2007; 32: 413–419.