Zafer Asım KAPLANCIKLI, Merve BAYSAL, Leyla YURTTAŞ, Zerrin CANTÜRK, Dahmane TEBBANI, Özlem ATLI, Gülhan TURAN-ZITOUNI, Aouatef TABBI

Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities

Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C NMR, and MS spectral data. Their antimicrobial activities againstStaphylococcus aureus(ATCC-25923),En-terococcus faecalis(ATCC-29212),Enterococcus faecalis(ATCC-51922),Listeria monocytogenes(ATCC-1911),Klebsiellapneumoniae(ATCC-700603),Pseudomonas aeruginosa(ATCC-27853),Escherichia coli(ATCC-35218),Escherichia coli(ATCC-25922),Candida albicans(ATCC-90028),Candida glabrata(ATCC-90030),Candida krusei(ATCC-6258), andCandida parapsilosis(ATCC-22019) were investigated. The compounds were also studied for their cytotoxic effects usinga MTT assay. Compound7cshowed the highest antimicrobial activity, possessing the same potential as chloramphenicolagainstK. pneumonia,P. aeruginosa, andE. coli(ATCC-25923).

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