Tijen ÖNKOL, M. Fethi ŞAHİN, Bilge ÇAKIR, Kevser EROL, Engin YILDIRIM

Synthesis and antinociceptive activity of 2-[(2-oxobenzothiazolin_3-yl)methlyl]-5-aminoalkyl/aryl-1,3,4,-thiadiazole

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and $^1H-NMR$ spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.

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