Field trial on cotton (Vega cultivar) was carried out during 2007-2012 on leached vertisols under irrigation regime of sprinkling – 75 % of the field moisture capacity (FMC) for the soil layer of 0 – 40 cm. The trial included the following variants: Factor A) Irrigation with lower rates: 1). Non-irrigated variant – for standard. 2). Two irrigations of 600 mm/ha at 75 % FMC in soil layer 0-40 cm – the first one at the blooming period and the second – at the boll formations period; 3). Two irrigations of 450 mm/ha at 75 % FMC in soil layer 0-40 cm – the first one at the blooming stage and the second – at the boll formations period; 4). Single irrigation of 600 mm/ha at 75 % FMC in soil layer 0-40 cm in the interphase period blooming - boll formations. Factor B) Width of inter-row space: 1). Inter-row space 60 cm - standard. 2). Inter-row space 80 cm. It was established that the best results were obtained at the variant where cotton cultivated of 80 cm inter-row space and with second time irrigation with 600mm - with 939 kg/ha more that non-irrigated control and with 11.9 % more then variant with irrigated norm 600 mm/ha. In reference of net profit of 1000 m3 irrigated water the best results were realized after single irrigation norm of 600 mm/ha. In respect of width of inter-row space the yield from a unit of area with inter-row space 80 cm we receive with 4.6 % more then sowing of 60 cm interrow space