Recurrent Intracranial Meningeal Hemangiopericytoma with an Isolated Bone Metastasis: A Case Report and Literature Review

Recurrent Intracranial Meningeal Hemangiopericytoma with an Isolated Bone Metastasis: A Case Report and Literature Review

Intracranial meningeal hemangiopericytoma is a rare vascular tumor with a high rate of both local recurrence and the development of distant metastases. The aim of this report is to present the first case of recurrent meningeal hemangiopericytoma with an isolated femur metastasis and discuss the clinical features and treatment of this rare tumor. A 46-year-old woman was admitted with the complaint of sudden loss of consciousness and subsequently underwent an urgent craniotomy with total excision of the lesion. The diagnosis was meningeal hemangiopericytoma. The patient presented with a painful left hip 5½ years after the initial surgery for the primary tumor. A lytic lesion, which was 4x4.5 cm in diameter, was seen on an X-ray of the proximal left femur. The patient underwent lesion removal surgery and pathological diagnosis was compatible with meningeal hemangiopericytoma. At 69th month, no progression has been observed in follow-up. Long-term follow-up is mandatory for meningeal hemangiopericytoma due to high recurrence rate many years after diagnosis. Further multi-institutional studies are strongly needed to understand the clinical behavior and treatment modalities of this rare disease

___

  • 1. Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE. Hemangiopericytoma of the central nervous system: a review of 94 cases. Hum Pathol 1991;22(1):84– 91.
  • 2. Someya M, Sakata KI, Oouchi A, Nagakura H, Satoh M, Hareyama M. Four cases of meningeal hemangiopericytoma treated with surgery and radiotherapy. Jpn J Clin Oncol 2001;31(11):548–52.
  • 3. Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring zimmermann’s pericytes. Ann Surg 1942;116(1):26–33.
  • 4. Ibis K, Saynak M, Yalta T, Ibis C, Kocak Z, Karadeniz A. Pancreas is an unusual initial metastatic site of intracranial hemangiopericytoma. Turk J Oncol 2016;31(2):55–60.
  • 5. Iwaki T, Fukui M, Takeshita I, Tsuneyoshi M, Tateishi J. Hemangiopericytoma of the meninges: a clinicopathologic and immunohistochemical study. Clin Neuropathol 1988;7(3):93–9.
  • 6. Hoshi M, Araki N, Naka N, Koizumi M, Hashimoto N, Onishi M, et al. Bone metastasis of intracranial meningeal hemangiopericytoma. Int J Clin Oncol 2005;10(3):208–13.
  • 7. Han N, Kim H, Min SK, Paek SH, Park CK, Choi SH, et al. Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis. J Pathol Transl Med 2016;50(2):113–21.
  • 8. Prakasha B, Jacob R, Dawson A, Joannides T. Haemangiopericytoma diagnosed from a metastasis 11years after surgery for “atypical meningioma”. Br J Radiol 2001;74(885):856–8.
  • 9. Kruse F. Hemangiopericytoma of the meniges (angioblastic meningioma of Cushing and Eisenhardt). Clinico-pathologic aspects and follow-up studies in 8 cases. Neurology 1961;11:771–7.
  • 10.Scott M, Kellett G, Peale A. Angioblastic meningioma (hemangiopericytoma) of the cerebellar fossa with metastases to the temporal bone and the lumbar spine. Surg Neurol 1974;2(1):35–8.
  • 11.Thomas HG, Dolman CL, Berry K. Malignant meningioma: clinical and pathological features. J Neurosurg 1981;55(6):929–34.
  • 12.Itoh Y, Kowada M, Sakamoto T, Kojima H. Electron microscopic study of metastatic hemangiopericytic meningioma. [Article in Japanese] No Shinkei Geka 1984;12(10):1187–93. [Abstract]
  • 13.Younis GA, Sawaya R, DeMonte F, Hess KR, Albrecht S, Bruner JM. Aggressive meningeal tumors: review of a series. J Neurosurg 1995;82(1):17–27.
  • 14.Koyama H, Harada A, Nakao A, Nonami T, Kurokawa T, Kaneko T, et al. Intracranial hemangiopericytoma with metastasis to the pancreas. Case report and literature review. J Clin Gastroenterol 1997;25(4):706–8.
  • 15.Nonaka M, Kohmura E, Hirata M, Hayakawa T. Metastatic meningeal hemangiopericytoma of thoracic spine. Clin Neurol Neurosurg 1998;100(3):228–30.
  • 16.Suzuki H, Haga Y, Oguro K, Shinoda S, Masuzawa T, Kanai N. Intracranial hemangiopericytoma with extracranial metastasis occurring after 22 years. Neurol Med Chir (Tokyo) 2002;42(7):297–300.
  • 17.Woitzik J, Sommer C, Krauss JK. Delayed manifestation of spinal metastasis: a special feature of hemangiopericytoma. Clin Neurol Neurosurg 2003;105(3):159– 66.
  • 18.Chang CC, Chang YY, Lui CC, Huang CC, Liu JS. Meningeal hemangiopericytoma with delayed multiple distant metastases. J Chin Med Assoc 2004;67(10):527– 32.
  • 19.Lee JK, Kim SH, Joo SP, Kim TS, Jung S, Kim JH, et al. Spinal metastasis from cranial meningeal hemangiopericytomas. Acta Neurochir (Wien) 2006;148(7):787– 90.
  • 20.Siegel HJ, Lopez-Ben R, Sutton JH, Siegal GP. Intracranial meningeal hemangiopericytoma metastatic to the scapula. Orthopedics 2012;35(1):112–5.
  • 21.Satayasoontorn K, Righi A, Gambarotti M, Merlino B, Brunocilla E, Vanel D. Meningeal hemangiopericytoma only diagnosed at the time of late bone metastasis. Skeletal Radiol 2014;43(11):1543–9.