Erişkin Still Hastalığında Belirgin Reaktif Trombositozis

Erişkin still hastalığı (ESH), bilinmeyen nedenlere bağlı gelişen multisistemik inflamatuvar bir hastalıktır. Ateş, artrit ve gövdede tipik olarak görülen somon renklidöküntülerle karakterizedir. Tanı genellikle benzer bulgularla seyreden hastalıkların dışlanmasına ek olarak klinik ve laboratuvar bulgularının birlikteliği ile konur.Lenfadenopati ve lökositoz gibi nonspesifik hematolojik bulgular ve farenjit mevcut olabilir. Reaktif trombositoz ESH’da beklenen bir durumken 1 milyonu geçentrombosit yüksekliği ise nadir görülen bir laboratuvar bulgusudur. Bu olguda erişkin still hastalığına eşlik eden belirgin reaktif trombositoz ve nötrofili ile takip ettiğimiz33 yaşında bir erkek hasta sunulmaktadır. ( Sakarya Tıp Dergisi 2019, 9(2):342-346)

Reactive Thrombocytosis In Adult Still Disease

Adult still disease (ASD) is a multi system inflammatory disease of unknown origin. It is an inflammatory disease characterized by fever, arthritis and salmon-colored rash typically seen in the body. The diagnosis is usually made by the association of clinical and laboratory findings in addition to exclusion of diseases with similar findings. Nonspecific hematological findings such as lymphadenopathy and leukocytosis and pharyngitis may be present. Reactive thrombocytosis may be seen but platelet levels exceeding 1 million is a rare laboratory finding. In this case report, we present a 33-year-old male patient who was followed with adult still disease and accompanying reactive thrombocytosis and neutrophilia. ( Sakarya Med J 2019, 9(2):342-346 )

PDF

___

1. Da Silva JAP, Woolf AD. Still’sdisease. In: Rheumatology in practice. 1st ed, London: Springer, 2010: 12-13.
2. Lisa A Mandl, James R O’Dell, Paul L Romain; Clinical manifestations and diagnosis of adult Still’sdisease-UpToDate 09.09.2018
3. Kontzias A, Eft himiou P. Adult-onset Still’s disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs 2008; 68: 319–37.
4. Yamaguchi, M, Ohta, A, Tsunematsu, T Preliminary criteria for classification of adult Still’s disease. J Rheumatol 1992; 19: 424–430.
5. Kadar J, Petrovicz E. Adult- onset Still’sdisease. Best PractResClinRheumatol 2004; 18: 663- 76
6. Fautrel B. Adult-onsetStilldisease. Best PractResClinRheumatol 2008; 22: 773-92.
7. Eft himiou P, Paik PK, Bielory L. Diagnosis and management of adult onset Still’s disease. AnnRheumDis 2006; 65: 564-72.
8. Cheema GS, Quismorio FP Jr. Pulmonary involvement in adult-onset Still’s disease. CurrOpinPulmMed 1999;5:305-309.
9. Pouchot J, Sampalis JS, Beaudet F, Carette S, Décary F, Salusinsky-Sternbach M, et al: AdultStill’sdisease: manifestations, diseasecourse, andoutcome in 62 patients. Medicine (Baltimore) 1991; 70: 118–136.
10. de Benedetti F, Massa M, Robbioni P, Ravelli A, Burgio GR, Martini A: Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. ArthritisRheum 1991; 34: 1158–1163.