Ismail Malkoc, Cengiz Ozturk, Mehmet Dumlu Aydin, Rabia Demirtas

Taste buds degeneration induced by lingual artery spasm in subarachnoid hemorrhage in rabbits

The role of the vasospasm induced by subarachnoid hemorrhage (SAH) in tongue taste bud degeneration is well established; however, the role of lingual artery spasm induced by SAH in that has not been efficiently studied. It was aimed to investigate the relationship between the taste buds degeneration and lingual artery spasm after SAH. Seventeen rabbits were randomizied into three groups: untouched control group (n=5), physiologic serum saline injected group (SHAM; n=6), and subarachnoid hemorrhage group (study; n=6). Experimental SAH was performed by injection 0.75 ml auricular arterial homologous blood was injected into cisterna magna three times in two weeks. After three weeks, all the rabbits were sacrificed and their tongues were removed under general anesthesia following intracardiac formalin injections. Normal and degenerated taste buds numbers and lingual artery vasospasm indexes were examined stereologically. Results were analyzed statistically with the Kruskal Wallis and the Mann Whitney U tests. Significance was accepted as p

PDF

___

Yamamoto T, Kawamura Y. Cortical responses to electrical and gustatory stimuli in the rabbit. Brain Res. 1975;94:447-63.
Benjamin RM, Burton H. Projection of taste nerve afferents to anterior opercular-insular cortex in squirrel monkey (Saimiri sciureus). Brain Res. 1968;7:221-31.
Ozdemir NG, Aydin MD, Yolas C, et al. Predictive role of external carotid artery vasospasm on cerebral ischemia after subarachnoid hemorrhage: experimental study. Turk Neurosurg. 2017;27:874-83.
Robinson PP, Winkles PA. The number and distribution of fungiform papillae and taste buds after lingual nerve injuries in cats. Arch Oral Biol. 1991;36:885-91.
Nagato T, Matsumoto K, Tanioka H, et al. Effect of denervation on morphogenesis of the rat fungiform papilla. Acta Anat (Basel). 1995;153:301-9.
Fan YY, Yu DM, Shi YJ, et al. Progress in the effects of injury and regeneration of gustatory nerves on the taste functions in animals. Sheng Li Xue Bao. 2014;66:519-27.
Kayipmaz S, Sezgin OS, Saricaoglu ST, et al. The estimation of the volume of sheep mandibular defects using cone-beam computed tomography images and a stereological method. Dentomaxillofac Radiol. 2011;40:165-6.
El-Khouly H, Fernandez-Miranda J, Rhoton AL Jr. Blood supply of the facial nerve in the middle fossa: The petrosal artery. Neurosurgery. 2008;62:297-303; discussion 303-4.
Zaidi FN, Whitehead MC. Discrete innervation of murine taste buds by peripheral taste neurons. J Neurosci. 2006;26:8243-53.
Miller IJ Jr, Gomez MM, Lubarsky EH. Distribution of the facial nerve to taste receptors in the rat. Chemical Senses. 1978;3:397-411.
Halpern BP, Nelson LM. Bulbar gustatory responses to anterior and to posterior tongue stimulation in the rat. Am J Physiol. 1965;209:105-10.
Grigaliunas A, Bradley RM, MacCallum DK, et al. Distinctive neurophysiological properties of embryonic trigeminal and geniculate neurons in culture. J Neurophysiol. 2002;88:2058-74.
Ozdemir NG, Aydın MD, Yolas C, et al. Predictive role of external carotid artery vasospasm on cerebral ischemia after subarachnoid hemorrhage: experimental study. Turk Neurosurg. 2017;27:874-83.
Takeda T, Takeda S, Kozakura K, et al. Intratemporal facial nerve blood flow in guinea pigs. Am J Otol. 1997;18:252-6.
Shigemura N, Islam AA, Sadamitsu C, et al. Expression of amiloridesensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush. Chem Senses. 2005;30:531-8.
Robinson PP, Winkles PA. The number and distribution of fungiform papillae and taste buds after lingual nerve injuries in cats. Arch Oral Biol. 1991;36:885-91.