Hayal Boyacıoğlu, Pelin Güneri, Ceyda Gürhan, Nezaket Ezgi Özer, Betül Karaca, Umut Aykutlu

Ağız Kanserinin Klinik Belirteçleri Değişiyor mu? Bir Örneklem Çalışması

Amaç: Çalışmanın amacı histopatolojik inceleme gerektiren oral lezyonların klinik özellikleri ve hastaların sübjektif semptomları değerlendirilerek, malignite riski ile ilişkili parametrelerin ve farklılık sergileyen klinik özelliklerin belirlenmesidir. Gereç ve Yöntemler: Yetmiş hastaya ait demografik veriler, lezyonların klinik özellikleri ve hastaların sübjektif semptomları ki-kare testi, Fisher bağımsızlık ve diskriminant analizi ile değerlendirildi. Bulgular: Lezyonun sınırları, rengi, lenfadenopati varlığı, lezyon farkındalığı, yüzey özellikleri, ülserasyon, fonksiyon kaybı ve ağrı malignite riski açısından önemli parametreler olarak belirlendi (p

Are Clinical Predictors of Oral Malignancy Risk Changing? A Sample Study

Objective: Our study assesss the clinical features of oral lesions that require histological examination and patient-reported symptoms to estimate the risk of malignancy and to determine the presence of any altered features. Materials and Methods: Demographic characteristics of 70 patients and clinical features of lesions were analyzed using chi-square test, Fisher’s Exact test of Independence and discriminant function analysis. Results: Margins, lymphadenopathy, patient’s self-awareness of the lesion associated with mass effect, surface texture, colour, ulceration, loss of function and pain were significant parameters indicating the risk of malignancy (p

PDF

___

1. Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review. Med Oral Patol Oral Cir Bucal 2015; 20: 305-15.
2. Güneri P, Epstein JB. Late-stage diagnosis of oral cancer: components and possible solutions. Oral Oncol 2014; 50: 1131- 6.
3. Ribeiro ACP, Silva ARS, Simonato LE, Salzedas LMP, Sundefeld MLMM, Soubhia AMP. Clinical and histopathological analysis of oral squamous cell carcinoma in young people: a descriptive study in Brazilians. Br J Oral Maxillofac Surg 2009; 47: 95-8.
4. Scully C, Bagan Jv. Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications. Oral Dis 2009; 15: 388-99.
5. Bagan J, Sarrion G, Jimenez Y. Oral cancer: clinical features. Oral Oncol 2010; 46: 414-17.
6. Scully C, Field JK, Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations. Oral Oncol 2000; 36: 311-27.
7. Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol 2009; 21: 194-200.
8. Bonifazi M, Malvezzi M, Bertuccio P, Edefonti V, Garavello W, Levi F, et al. Age-period-cohort analysis of oral cancer mortality in Europe: the end of an epidemic? Oral Oncol 2011; 47: 400-7.
9. Olaleye O, Ekrikpo U, Lyne O, Wiseberg J. Incidence and survival trends of lip, intra-oral cavity, and tongue base cancers in south- east England. Ann R Col Surg Engl 2015; 97: 229-34.
10. Ingafou M, Leao JC, Porter SR, Scully C. Oral lichen planus: a retrospective study of 690 British patients. Oral Dis 2006; 12: 463-8.
11. Gooi Z, Chan JYK, Fakhry C. The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 2016; 126: 894-900.
12. Alsidawi S, Price KA, Chintakuntlawar AV, Westin GF, Garcia JJ, Ma DJ, et al. Characteristics and long-term outcomes of head and neck squamous cell carcinoma after solid organ transplantation. Oral Oncol 2017; 72: 104-9.
13. Boyle P, Autier P, Bartelink H, Baselga J, Boffetta P, Burn J, et al. European Code Against Cancer and scientific justification: third version (2003). Ann Oncol 2003; 14: 973-1005.
14. Walsh T, Liu JLY, Brocklehurst P, Glenny A-M, Lingen M, Kerr AR, et al. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. Cochrane Database Syst Rev 2013; 2013: CD010173.
15. Poh CF, MacAulay CE, Laronde DM, Williams PM, Zhang L, Rosin MP. Squamous cell carcinoma and precursor lesions: diagnosis and screening in a technical era: Diagnosis & screening advances. Periodontol 2000 2011; 57: 73-88.
16. Omar E. Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma--a systematic review. Head Face Med 2015; 25: 11-6