The impact of pregnancy rates of using two different cut-off levels for high serum estradiol levels on the day of the hCG injection: Results from the same cohort of patients with long down-regulated ART cycles

Amaç: Üremeye yardımcı tedavi (ÜYT) uygulanan hasta kohortunda insan koriyonik gonadotropin (hCG) günü oluşturulan iki farklı serum östradiol (E2) eşik değerlerinin ÜYT gebelikleri üzerine etkilerinin araştırılması. Hastalar ve Yöntem: Üniversiteye bağlı eğitim hastanesinde uzun süreli gonadotropin salgılayıcı hormon baskısından sonra kullanılan rekombinant folikül stimüle edici hormon (FSH) ile ÜYT alan 539 ardışık kadın retrospektif analize alınmıştır. hCG günü alınan serum E2 seviyesinin yüksek eşik değeri persentil analizine göre yapılmıştır. Grup 1 için serum E2 seviyeleri 25 75inci persentilde (1040-2500pg/ml)olanlar alt grup A ; serum E2 seviyeleri 75100üncü persentilde (>2500pg/ml)olanlar alt grup B olarak ayrılmıştır. Grup 2 için serum E2 seviyeleri 10 90ıncı persentilde olanlar(650-3100pg/ml) alt grup A ve serum E2 seviyeleri 90100üncü persentilde (>3100pg/ml)olanlar alt grup B olarak ayrılmıştır. Klinik ve devam eden gebelik oranları karşılaştırılmıştır. Bulgular: Hem grup 1de hem de grup 2de klinik ve gebelik oranları benzerdir. Sonuç: hCG günü serum E2 seviyelerinin eşik değeri 75inci (2500pg/ml), veya 90ıncı persentil (3100pg/ml) üzerinde olması GnRH analogları ile baskılanmış uzun protokol ÜYT sikluslarında gebelik oranlarını olumsuz etkilememektedir.

Aynı hasta kohortunda hCG günü oluşturulan iki farklı serum östradiol eşik değerlerinin ÜYT gebelikleri üzerine etkileri

Objective: To determine, from a single cohort of patientwhether on the day of the human chorionic gonadotropin (hCG) injection, two different cut-off levels for high serum estradiol (E2) levels affect pregnancy rates in long-down regulated assisted reproductive technology (ART) cycles. Patients and Methods: A retrospective cohort analysis waperformed in a University affiliated hospital on 539 womeundergoing consecutive in vitro fertilization/intacytoplasmic sperm injection (IVF/ICSI) treatment with long-down regulation anrecombinant follicular stimulating hormone (FSH) injections. Thcut-off level for high E2 concentration was calculated according ta centile analysis of E2 levels on the day of hCG administrationWomen in group 1 were divided into subgroup A with E2 levels from the 25th to 75th centiles (1040-2500pg/ml) and subgroup B with Elevels from the 75th to 100th centiles (>2500pg/ml), respectivelyWomen in group 2 were divided into subgroup A with E2 levelfrom the 10th to 90th centile (650-3100pg/ml) and subgroup B witE2 levels from the 90th to 100th centile (>3100pg/ml), respectivelyThe clinical pregnancy rates and ongoing pregnancy rates wercompared. Results: The clinical pregnancy rates and ongoing pregnancrates were similar in group 1 and group 2. Conclusion: High serum E2 levels on the day of the hCG injection day either set at 75th (2500pg/ml) or 90th percentile(3100pg/ml) do not compromise pregnancy rates in cycles downregulated with gonadotropin-releasing hormone (GnRH) analogues

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