Yükselmiş Kırmızı Kan Hücresi Dağıtım Genişliği İzole Sistolik Hipertansiyon ile İlişkilidir

Giriş: Bu çalışmanın amacı, izole sistolik hipertansiyon ve kırmızı kan hücresi dağılım genişliği (RDW) arasındaki ilişkiyi belirlemektir. Hastalar ve Yöntem: Toplam 81 hasta çalışmaya dahil edildi. Kan basıncı manuel sfingomanometre kullanarak bir kardiyolog tarafından ölçüldü ve hastalar Avrupa Hipertansiyon Topluluğu sınıflandırmasına dayalı olarak normotansif ve izole sistolik hipertansif olarak iki gruba ayrıldı. Tam kan sayımı ve her hastanın biyokimyasal değerleri standart yöntemler kullanılarak ölçüldü. Bulgular: İzole sistolik hipertansif ve normotansif grupların ortalama RDW değerleri arasında anlamlı bir fark tespit edildi. Yüksek RDW değerleri ve izole sistolik hipertansiyon arasında güçlü bir ilişki varken, diğer ölçülen laboratuvar değerleri bakımından iki grup arasında anlamlı farklılık yoktu. Sonuç: Yüksek RDW değeri izole sistolik hipertansiyon için güçlü ve bağımsız bir belirleyici olarak tespit edildi.

Anahtar Kelimeler:

Kırmızı kan hücresi dağılım genişliği, hipertansiyon, eritrosit indeksleri

Elevated Red Blood Cell Distribution Width is Associated with Isolated Systolic Hypertension

Introduction: The aim of this study was to determine the relationship between isolated systolic hypertension and red blood cell distribution width (RDW). Patients and Methods: Eighty-one patients were included in the study. Blood pressure was measured by a cardiologist using a manual sphygmomanometer, and the patients were divided into 2 groups as isolated systolic hypertensive and normotensive based on the European Society of Hypertension classification. Complete blood counts (CBC) and biochemical values of each patient were measured using standard methods. Results: There was significant difference between the mean RDW values of the isolated systolic hypertensive and the normotensive groups. While there was a strong association between high RDW values and isolated systolic hypertension, there were no significant differences between the 2 groups for any of the other measured laboratory values. Conclusion: High RDW value appears to be a strong and independent predictor of isolated systolic hypertension.

Keywords:

Red cell distribution width, hypertension, erythrocyte indices,

PDF

___

1. Means RT Jr. Free and easy? Red cell distribution width (RDW) and prognosis in cardiac disease. J Card Fail 2011;17:299-300.
2. Uyarel H, Ergelen M, Cicek G, Kaya MG, Ayhan E, Turkkan C, et al. Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis 2011;22:138-44.
3. Balta S, Aydogan M, Kurt O, Karaman M, Demirkol S, Akgul EO. Red cell distribution width as a novel, simple, inexpensive predictor of mortality in patients with chronic heartfailure. Int J Cardiol 2013;168:3049-50.
4. Warwick R, Mediratta N, Shaw M, McShane J, Pullan M, Chalmers J, et al. Red cell distribution width and coronary artery bypass surgery. Eur J Cardiothorac Surg 2013;43:1165-9.
5. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R; Prospective Studies Collaboration. Prospective Studies Collaboration. Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903-13.
6. Blacher J, Staessen JA, Girerd X, Gasowski J, Thijs L, Liu L, et al. Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch Intern Med 2000;160:1085-9.
7. Hajjar IM, Grim CE, George V, Kotchen TA. Impact of diet on blood pressure and age-related changes in blood pressure in the US population: analysis of NHANES III. Arch Intern Med 2001;161:589-93.
8. Staessen JA, Gasowski J, Wang JG, Thijs L, Den Hond E, Boissel JP, et al. Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet 2000;355:865-72.
9. Kannel WB. Fifty years of Framingham Study contributions to understanding hypertension. J Hum Hypertens 2000;14:83-90.
10. Mallion JM, Hamici L, Chatellier G, Lang T, Plouin PF, De Gaudemaris R. Isolated systolic hypertension: data on a cohort of young subjects from a French working population (IHPAF). J Hum Hypertens 2003;17:93-100.
11. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al: Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42:1206-52.
12. Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation 2001;103:1245-9.
13. Vaccarino V, Berger AK, Abramson J, Black HR, Setaro JF, Davey JA, et al. Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program. Am J Cardiol 2001;88:980-6.
14. Stamler J, Stamler R, Neaton JD. Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med 1993;153:598-615.
15. Makhoul BF, Khourieh A, Kaplan M, Bahouth F, Aronson D, Azzam ZS. Relation between changes in red cell distribution width and clinical outcomes in acute decompensated heart failure. Int J Cardiol 2013,167:1412-6.
16. Olivares Jara M, Santas Olmeda E, Miñana Escrivà G, Palau Sampio P, Merlos Díaz P, Sanchis Forés J, et al. Red cell distribution width and mortality risk in acute heart failure patients. Med Clin 2013;140:433-8.
17. Gul M, Uyarel H, Ergelen M, Karacimen D, Ugur M, Turer A, et al. The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up. Coron Artery Dis 2012;23:330-6.
18. Kalay N, Aytekin M, Kaya MG, Ozbek K, Karayakalı M, Söğüt E, et al. The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels. Turk Kardiyol Dern Ars 2011;39:463-8.
19. Dogdu O, Koc F, Kalay N, Yarlioglues M, Elcik D, Karayakali M, et al. Assessment of red cell distribution width (RDW) in patients with coronary artery ectasia. Clin Appl Thromb Hemost 2012;18:211-4.
20. Tanindi A, Topal FE, Topal F, Celik B. Red cell distribution width in patients with prehypertension and hypertension. Blood Press 2012;21:177-81.
21. Gunebakmaz O, Kaya MG, Duran M, Akpek M, Elcik D, Eryol NK. Red blood cell distribution width in ‘non-dippers’ versus ‘dippers’. Cardiology 2012;123:154-9.
22. Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol 2010;15:37-40.
23. Fornal M, Wizner B, Cwynar M, Królczyk J, Kwater A, Korbut RA, et al. Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension. Clin Hemorheol Microcirc 2014;56:325-35.
24. Ozcan F, Turak O, Durak A, Işleyen A, Uçar F, Giniş Z, et al. Red cell distribution width and inflammation in patients with non-dipper hypertension. Blood Press 2013;22:80-5.
25. Douglas SW, Adamson JW. The anemia of chronic disorders: studies of marrow regulation and iron metabolism. Blood 1975;45:55-65.
26. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
27. Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T, et al. Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor. FASEB J 2005;19:2023-35.
28. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients. Scand J Clin Lab Invest 2008;68:745-8.

ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi