İZOLE PEDİATRİK KAFA TRAVMALARINDA MMP-9 VE E-SELEKTİN DÜZEYLERİNİN ARAŞTIRILMASI

Amaç: Bu çalışmadaki amacımız, izole pediatrik kafa travmalarında meydana gelen hasarda Matriks Metalloproteinaz-9 (MMP-9) ve E-selektintin düzeylerinin nasıl etkilendiğini tespit etmektir. Aynı zamanda bu parametrelerin bu vakalardaki biyokimyasal açıdan değerini araştırmak, konuyla ilgili yeni görüşler ileri sürebilmek hedeflenmiştir.

Anahtar Kelimeler:

Pediatrik kafa travması, matriks metalloproteinaz-9, E-Selektin

Investigation of MMP-9 and E-Selectine Levels in Isolated Pediatric Head Trauma

Objective: Our aim in this study was to determine how Matrix Metalloproteinase-9 (MMP-9) and E-selectin levels are affected in the damage caused by isolated pediatric head trauma. At the same time, it was aimed to investigate the value of these biochemical parameters in these cases and to propose new opinions on the subject.

Keywords:

Pediatric Head Trauma, E-Selectin, matrix metalloproteinase-9,

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1. Marshall LF, Marshall SB Grady MS. Modern neurotraumatology: A brief historical review In: Winn HR, Youmans JR, eds. Youmans Neurological Surgery, 5th ed. Philadelphia. Saunders 4, 2004:5019-24.
2. Şahinoğlu AH. Yoğun Bakım Sorunları ve Tedavileri 2. Baskı, Ankara, Türkiye Klinikleri. 2003;331-6.
3. Buchman TG, Bowling WM, Kelen GD. Thoracic Trauma. Cline DM, Ma OJ, Tintinalli JE. Emergency Medicine. 5th ed. America. Mc Graw Hill View CO., 2002.
4. Allgöwer M. Trauma systems in Europe. Am J Surgery. 1991;161(2):226-9.
5. Longhi L, Saatman K. Cellular basic of injury and recovery from trauma. In: Winn HR, ed. Youmans Neurological Surgery. Philadelphia. Saunders, 1996:5025-33.
6. Zwienenberg-Lee M, Muizelaar J. Clinical Pathophysiology of Traumatic Brain Injury. Youmans Neurological Surgery. 5th ed. Philadelphia. Saunders. 2004.
7. Campbell JW, Adelson PD. Severe closed head ınjury in children. In: Batjer HH, Loftus CM, eds. Textbook of Neurological Surgery. Baltimore, USA. Lippincott, Williams & Wilkins, 2002:1072-8.
8. Alexander R, Proctor H. Head Trauma, Advanced Trauma Life Support. 3rd ed. Chicago. American College of Surgeons, 1993.
9. Ceviker N, Baykaner K, Keskil S, Cengel M, Kaymaz M. Moderate head injuries in children as compared to other age groups, including the cases who had talked and deteriorated. Acta Neurochirurgica. 1995;133(3-4):116-21.
10. Ertekin C, Güloğlu R, Kurtoğlu M, Uzar Aİ, Kayahan C. Kinematics of Trauma, 1. Baskı, İstanbul: İstanbul Medikal Yayıncılık. 2005;33-45.
11. Carney NA, Ghajar J. The Brain trauma foundation. Guidelines for the management of severe traumatic brain injury. J Neurotrauma. 2007;24(1):1-2.
12. Uçar T. Skalp yaralanmaları. Aksoy K, ed. Temel Nöroşirürji. 1. baskı. Ankara. Türk Nöroşirurji Derneği Yayınları, 2005:342-5.
13. Yeşilağaç H. Güncel Acil Tanı Tedavi. 5. baskı. İstanbul. Nobel Kitabevi, 2006.
14. Bekar A, Bozbuğa M, Çelikoğlu E, Savaş A, Aydın Y, Müslüman M ve ark. Kafa travması. In: Ertekin C, Tavioloğlu K, Güloğlu R, eds. Travma. 1. baskı. İstanbul. İstanbul Medikal Yayıncılık, 2005:654-64.
15. Buket R. Matrix metalloproteinaz enzimleri ve ateroskleroz. Türkiye Klinikleri J Med Sci. 2006;26(5):527-37.
16. Zeng ZS. Loss of basement: membrane type IV collagen is associated with increased expression of Metalloproteinases 2 and 9 during human colorectal tumorigenesis. Carsinogenesis. 1999;20(5):749-55.
17. John A, Tuszynski G. The role of Matrix Metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res. 2001;7(1):14-23.
18. Matsuyama A, Sakai N, Ishigami M, Hiraoka H, Kashine S, Hirata A et al. Matrix metalloproteinases as novel disease markers in takayasu arteritis. Circulation. 2003;108(12):1469-73.
19. Mackay CR, Imhof BA. Cell adhesion in the immune system. Immunol Today. 1993;14(3):99-102.
20. Elangbam CS, Qualls CW, Dahlgren RR. Cell adhesion molecules update. Vet Pathol. 1997;34(1):61-73.
21. Jung U, Ley K. Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin. J Immunol. 1999;162(11):6755-62.
22. Tekereci HM, Şahan B, Top C. Hücre adezyon molekülleri. Nobel med. 2008;4(1):4-10.
23. Roldan V. Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature. Thromb Haemost. 2003;90(6):1007-20.
24. Mandal M, Mandal A, Das D, Chakraborti T, Sajal C. Clinical implications of matrix metalloproteinases. Mol Cell Biochem. 2003;252(1-2):305-29.
25. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases. Structure, function and biochemistry. Circ.Res. 2003;92(8):827-39.
26. Muphy G, Willenbrock F, Crabbe T. Regulation of matrix metalloproteinases activity. Ann Ny Acad Sci. 1994;732(1):31-41.
27. Cojocarui IM, Cojocaru M, Sapira V. Changes in plasma matrix metalloproteinase-9 levels in patients with acute ischemic stroke. Rom J Intern Med. 2012;50(2):155-8.
28. Eckart RE, Uyehara CFT, Shry EA. Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization. J Interven Cardiol. 2004;17(1):27-31.
29. Susskind H, Hymowitz MH, Lau YH, Atkins HL, Hurewitz AN, Valentine ES et al. Increased plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung and breast cancer are altered during chest radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56(4):1161-9.
30. Sagar R, Kumar A, Verma V, Yadav AK, Raj R, Rawat D et al. Incremental accuracy of blood biomarkers for predicting clinical outcomes after ıntracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2021;30(3):105537.
31. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 2007;147(2):227-35.
32. Kumar V, Abbas AK. Aster JC. Inflammation and Repair Robbins Basic Pathology. 9th ed. Philadelphia. Elsevier, 2013.
33. Mackay CR, Imhof BA. Cell adhesion in the immune system. Immunol Today. 1993;14(3):99-102.
34. Paulson JC. Selectin/carbohydrate-mediated adhesion of leukocytes. In: Harlan JM, Lui DY, eds. Adhesion: Its Role in Inflamatory Disease. New York. W.H. Freeman, 1992:104-35.
35. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J. 1994;8(8):504-12.
36. Blankenberg S, Rupprecht HJ, Bickel C, Peetz D, Hafner G, Tiret L et al. Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation. 2001;104(12):1336-42.
37. Kamijikkoku S, Murohara T, Tayama S, Matsuyama K, Honda T, Ando M et al. Acute myocardial infarction and increased soluble intercellular adhesion molecule-1: a marker of vascular inflammation and a risk of early restenosis? Am Heart J. 1998;136(2):231-6.
38. Nash MC, Wade O, Shah V, Dillon MJ. Normal levels of soluble E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease with age. Clin Exp Immunol. 1996;103(1):167-70.
39. Bevilacqua MP. Endothelial-lukocyte adhesion molecules. Ann Rev of Immunol. 1993;11(1):767-804.