Romatoit Artritte Hastalık Aktivitesinin Nötrofil lenfosit Oranı ve Ortalama Trombosit Hacmi ile İlişkisi

Amaç: Romatoid Artrit (RA), simetrik eroziv sinovit ile karakterize, kronik sistemik inflamatuvar bir hastalıktır. Nötrofil lenfosit oranı (NLO) ve ortalama trombosit hacmi (OTH) ise inflamasyonun şiddetini belirlemek için kullanılan yeni belirteçlerdir. Biz bu çalışma ile RA'de hastalık aktivitesi ile NLO ve OTH değerleri arasındaki ilişkiyi ortaya koymayı amaçladık. Gereç ve Yöntemler: Bu retrospektif çalışma Mart 2012 ile Mart 2013 arasında yapıldı. Çalışmaya toplam 156 RA hastası dahil edildi. Bulgular: NLO aktif hastalık grubunda remisyon grubuna göre daha yüksekti, ancak remisyon grubu ile aktif hastalık grubu arasında anlamlı fark yoktu (p: 0.616). Düşük hastalık aktivitesi grubunda, orta derecede hastalık aktivitesi grubunda ve yüksek hastalık aktivite grubunda NLO sırasıyla 1.98 ± 0.71, 2.26 ± 1.04 ve 3.11 ± 2.16 idi. Karşılaştırılan gruplar arasında istatiksel olarak anlamlı fark mevcuttu (p: 0.030). Remisyon grubu ve aktif hastalık grubunun OTH değerleri sırasıyla 8.54 ± 0.78 ve 8.89 ± 0.99 fl idi ve gruplar arasında anlamlı fark yoktu (p: 0.126). Ayrıca remisyon grubu, düşük hastalık aktivite grubu, orta hastalık aktivite grubu ve yüksek hastalık aktivite grubunda OTH sırasıyla 9.31 ± 1.09, 8.91 ± 0.98, 8.71 ± 0.97 fl idi. Daha yüksek hastalık aktivitesi olan hastalarda OTH azalmasına rağmen, gruplar arasında anlamlı fark mevcut değildi (p: 0.206). Sonuç: NLO, RA hastalarında hastalık aktivitesini değerlendirmek için faydalı bir belirteçtir. Artan NLO değerleri artmış hastalık aktivitesine işaret eder. Fakat OTH değerlerinin RA hastalarında hastalık aktivite göstergesi olarak kullanılabilmesi için daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

Nötrofil lenfosit Oranı, Ortalama Trombosit Hacmi, Romatoit Artrit

Relation of Disease Severity with Neutrophil Lymphocyte Ratio and Mean Platelet Volume in Rheumatoid Arthritis

Objective: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by symmetrical erosive synovitis. The neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) have been widely used to determine the severity of inflammation. Objectives: We aimed to investigate NLR and MPV values in RA population further assessing the relation between these indices, inflammatory markers and disease activity scores. Material and Methods: The present study was performed between March 2012 and March 2013, and designed retrospectively. Total 156 patients of RA were included. Results: The NLR was higher in active disease group but there was not significant difference between the remission group and active disease group (p: 0.616). Also NLR of low disease activity group, moderate disease activity group and high disease activity group were 1.98±0.71, 2.26±1.04, and 3.11±2.16 respectively. There is significant difference between groups (p: 0.030). The MPV of remission group and active disease group were 8.54±0.78 fl and 8.89±0.99 fl, respectively and there is no significant difference between both groups (p: 0.126). Also the MPV of remission group, low disease activity group, moderate disease activity group and high disease activity group were 9.31±1.09 fl, 8.91±0.98 fl, 8.71±0.97 fl, respectively. Although MPV is reduced in patients with higher disease activity, it was found that there was no significant difference between the groups (p: 0.206). Conclusions: NLR can be a useful marker to assess disease activity in RA patients. Increased NLR values may indicate increased disease activity. Whereas, there is a need for comprehensive studies to claim that average platelet volume as an indicator of disease severity in RA patients.

Keywords:

Neutrophil Lymphocyte Ratio, Mean Platelet Volume, Rheumatoid Arthritis,

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