Duygu ÇAKIROĞLU, YÜCEL MERAL, Didem KAZANCI, A. Arda SANCAK

Köpeklerde hipotiroidizm teşhisinde protirelin stimulasyon testinin yeri.

Hipotiroidizm köpeklerde sık görülen bir endokrinopatidir. Teşhiste ilk seçenek olan TSH stimulasyon testi zor ve pahalı bir testtir. Bu çalışmada klinik olarak hipotiroidi semptomları gösteren 10 köpekte TRH stimulasyon testi uygulanmıştır. Bunlardan düşük bazal TT4 değerine sahip 3 köpeğin normal TRH stimulasyonu gösterdiği, 3 köpeğin hem bazal TT4 değerlerinin hem de stimulasyon düzeyinin normal olduğu, normal bazal TT4 seviyelerine sahip dört köpeğin ise yeterli stimulasyon vermediği tespit edilmiştir. Sonuç olarak, TRH stimulasyon testinin, hipotiroidizm ihtimalini güvenilir şekilde ekarte ettiği, fakat TRH stimülasyon testi sonucunda yetersiz uyarımın, hipotiroidizm şüpheli olarak değerlendirilebileceğinden yola çıkılarak, TSH stimülasyon testinin hem pahalı olması, hem de bulunamaması nedeniyle, Protirelinin köpeklerdeki hipotiroidizmin ön tanısı için kullanılabileceği kanısına varıldı.

Anahtar Kelimeler:

tanı teknikleri, köpek, hipotiroidizm, tiroit hastalıkları, endokrin hastalıkları, tiroid hormonları, ilaçlar

Place of protirelin stimulation test In canine hypothyroidism diagnosis

Hypothyrodism is a common endocrinopathy in dogs. The first alternative in diagnosis is TSH stimulation test, which is expensive and unavailable. In this study, TRH stimulation test was applied to 10 dogs with clinical hypothyroidism symptoms. It was observed that 3 dogs with low basal TT4 values showed normal stimulation, 3 dogs had both normal basal TT4 values and stimulation, where 4 dogs with normal basal TT4 values did not reveal normal stimulation with TRH. In conclusion, since TRH stimulation test reliably eliminates hypothyroidism, but insufficient stimulation may be evaluated as suspicious hypothyroidism, because of the expensiveness and inavailability of TSH stimulation test, Protirelin may be used as the first step in diagnosis of hypothyroidism.

Keywords:

diagnostic techniques, dogs, hypothyroidism, thyroid diseases, endocrine diseases, thyroid hormones, drugs,

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