Osman KUTSAL, Atalay Sevil VURAL, HİLAL Handan ARSLAN, ASLAN KALINBACAK

Concurrent peritoneal mesothelioma and uterine adenocarcinoma in a rabbit (Oryctolagus cunıculus)

Bu olguda 5 yaşlı, dişi bir tavşanda gözlenen peritoneal mezotelyoma ve uterus adenokarsinomu bulguları klinik, morfolojik ve immunohistokimyasal olarak tanımlandı. Klinik olarak hayvan anemik, anorektik ve halsizdi, karın şişkindi. Uitrasonografide tüm hepatik loblar arasında anekoik alanlar görüldü. Nekropside omentum, barsak ve uterus serozası ile diyaframada 0.5-1.5 cm çapında, çok sayıda, sert, yuvarlak gri-beyaz nodüller vardı. Ayrıca, kalınlaşmış olan sağ uterus mukozası üzerinde de 2-7 mm çapında, çok sayıda, sert, yuvarlak, grimsi nodüller gözlendi. Akciğerlerde de yaklaşık l mm çapında benzer nodüllere rastlandı. Mikroskopik incelemede ise iki farklı tümörle karşılaşıldı. Bunlardan biri periton ve serosal yüzeylerde saptanan mezotelyoma; diğeri ise uterusta adenokarsinom ve bunun akciğer metastazı idi. Mezotelyoma, solid ya da papiller dizilimli; oval ya da yuvarlak çekirdekli, eozinofilik vakuoler sitoplazmalı yuvarlak veya polihedral görünümlü hücrelerden ibaretti. Bu hücreler Alcian blue, anti-kalretynyn, -vimentin ve -cytokeratine ile pozitif reaksiyon verdi. Uterus adenokarsinomu ve akciğer metastazı ise büyük, geniş sitoplazmalı pleomorfik hücrelerden oluşmuştu. Bu hücreler ise anti-carcinoembriogenic antigen ve S-100 proteini ile pozitif reaksiyon gösterdi.

Anahtar Kelimeler:

Oryctolagus cuniculus, adenokarsinom, olgu sunumları, klinik görünüm, sitoloji, iç zar tümörü, metastaz, neoplazma, karın zarı, tavşan

Bir Tavşanda (Oryctolagus cuniculus) rastlanan peritoneal mezotelyoma ve uterus adenokarsinomu

In this case report, peritoneal mesothelioma, and uterine adenocarcinoma were described with clinical, morphological, and immunohistochemical findings in a five year-old female rabbit. Clinical abnormalities included anemia, anorexia, dull demeanour, and droopy. Abdomen was distended with a few fluid, and anechoic areas were seen between all hepatic lobes on ultrasonography. At necropsy, nodules were seen as multiple firm, round, white-gray 0.5 cm to 1.5 cm in diameter in the peritoneal surfaces of :he omentum, intestine, uterus, diaphragma. Also, the right uterine . mucosa was thickened, and it was included multiple round, hard, grayish nodules 2 mm to 7 mm in diameter and their metastatic nodules were seen in the lungs. Microscopically, there were seen two types tuinorsf The first one, mesothelioma in the periton and peritoneal surface:; was composed of round to polyhedral large epithelial cells with round to oval nuclei, and eosinophilic vacuolated cytoplasma. They were formed solid nests or projecting in a papillary pattern. The neoplastic cells were stained positively with Alcian blue, and also, antibodies to kalretynyn, vimentin and cytokeratine. The other one, uterine adenocarcinoma and metastatic adenocarcinomas to lung were consisted of large and pleomorphic cells and had abundant cytoplasm. The neoplastic cells in the endometrium and lungs were reacted with antibodies to carcinoembriogenic antigen and S-100 protein.

Keywords:

Oryctolagus cuniculus, adenocarcinoma, case reports, clinical aspects, cytology, mesothelioma, metastasis, neoplasms, peritoneum, rabbits,

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