Kok Tong WONG, Hasnah OSMAN, Thaigarajan PARUMASİVAM, Jafri Malin ABDULLAH, Mohd. Zaheen HASSAN, Mohamad Nurul Azmi MOHAMAD TAİB

Antimalarial Evaluation of the Chemical Constituents Isolated from Dendrocalamus asper

Bamboo shoots of Dendrocalamus asper is very important for human health because of its high content of dietary fiber, low sugar, negligible amount of fat, rich in vitamins and minerals. In search of new potential antimalarial agents, the chemical constituents of bamboo shoots were evaluated againts the P. falciparum strain 3D7. One new metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with the four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3), 1-methoxy-4-(methoxymethyl)benzene (4) and 4-hydroxybenzaldehyde (5) were isolated from the crude extract using chromatographic methods: MPLC, UPLC/MS, analytical and preparative HPLC. Among these, compounds 1, 3 and 4 showed promising antimalarial activity with IC50 between 0.8-2.2 μg/mL. The molecular docking between the most potent compound 3 and dihydrofolate reductase-thymidylate synthase (DHFR-TS) was done to understand and exploring ligand-receptor interactions and hypothesize the compound's refinements

Keywords:

Dendrocalamus asper, antimalarial, P. Falciparum, Molecular docking, dihydrofolate reductase-thymidylate synthase (DHFR-TS),

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Journal of the Turkish Chemical Society Section A: Chemistry-Cover

Başlangıç: 2014
Yayıncı: Türkiye Kimya Derneği

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