SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES
SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES
Hydrazones were considered as signiŞcant substrates in drug discovery process. Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents. The synthesizedcompounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis C, H, N . Allcompounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds,8, 7, 6, and 4 showed excellent activities IC50 i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and22.95±0.47 µM, respectively. This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors
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- Pandey et al, 2000 Pandey, Devendra; Kumar, Ajendra; Nag, AK (2000). Asian Journal of Chemistry, 12, 1361
- Qu et al, 2015 Qu, Dan; Niu, Fang; Zhao, Xinlu; Yan, Ke-Xiang; Ye, Yu-Ting; Wang, Jia; Zhang, Mei; You, Zhonglu (2015). Bioorganic & medicinal chemistry, 23, 1944-1949
- Scavenging, 2015 Scavenging, DPPH Radical (2015). J. Chem. Soc. Pak, 37, 479
- Shakir et al, 2015 Shakir, M; Abbasi, A (2015). Journal of Chemical and Pharmaceutical Research, 7, 375-382
- Tan et al, 2013 Tan, Lirong; Su, Jiyan; Wu, Dianwei; Yu, Xiaodan; Su, Zuqing; He, Jingjin; Wu, Xiaoli; Kong, Songzhi; Lai, Xiaoping; Lin, Ji; others (2013). The ScientiŞc World Journal, 2013
- Verma et al, 2014 Verma, Garima; Marella, Akranth; Shaquiquzzaman, Mohammad; Akhtar, Mymoona; Ali, Mohammad Rahmat; Alam, Mohammad Mumtaz (2014). Journal of pharmacy & bioallied sciences, 6, 69
- ISSN: 2651-4338
- Başlangıç: 2012
- Yayıncı: SciMatic Yazılımları Danışmanlık
Sayıdaki Diğer Makaleler
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SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES