İpek ULU, Şule YILDIRIM KÖPÜK, Yasemin ÇEKMEZ, Gürkan KIRAN

Prokinetisin 1 preeklampsi belirteci olarak kullanılabilir mi?

Prokinetisin 1 preeklampsi belirteci olarak kullanılabilir mi? Amaç: Prokinetisinler, gastrointestinal sistemde görev aldığı saptanan bir grup peptidden oluşur ve 3 alt gruba ayrılır. Anjiogenezde, hematopoezde ve üremede önemli rolleri olduğu saptanmıştır. Anjiogenezde vasküler endotelyal büyüme faktörüne (VEGF) benzer rol aldığından dolayı EG-VEGF (endokrin gland kaynaklı vasküler endotelyal büyüme faktörü) olarak da adlandırılır. Bağışıklık sistemiyle de ilişkili olduğu gösterilen prokinetisinlerin kadın genitoüriner sistemini en çok etkileyen alt grubu prokinetisin 1’dir (PROK1). PROK1 sinsityotrofoblastlardan salınmakta olup plasentanın büyüme ve matürasyonu için hayati öneme sahiptir. PROK1, extravillöz trofoblastik hücre göçünü ilk trimesterde engeller. Hipoksi, PROK1’in ekspresyonunu uyararak preeklamptik gebelerde serum PROK1 düzeyini arttırır. Bu çalışma ile PROK 1 preeklampsi (PE) öngörüsünde bir belirteç olarak kullanabilir mi sorusuna cevap aramaktayız. Gereçler ve Yöntem: Çalışmaya Ümraniye Araştırma ve Eğitim Hastanesi Kadın Hastalıkları ve Doğum Kliniği'nde Ekim 2016-Eylül 2017 tarihleri arasında başvuran 84 gebe dahil edildi. PE tanısı alan 43 gebe vaka grubuna, 41 sağlıklı gebe kontrol grubuna dahil edildi. PE grubu; hafif PE (n=27) ve şiddetli PE (n=16) olmak üzere iki alt gruba ayrıldı. Bulgular: Gruplar arasında anne yaşı (yıl) ve başvuru sırasındaki gebelik yaşı açısından anlamlı bir fark saptanmadı. Doğum haftası, PE grubunda kontrol grubuna göre anlamlı olarak daha kısaydı (38.8 ± 1.43'e karşı 35.93 ± 3.5; p

Anahtar Kelimeler:

preeklampsi, prokinetisin 1, belirteç

Can prokineticin 1 be used as a biomarker in preeclampsia?

Abstract Can prokineticin 1 be used as a biomarker in preeclampsia? Aim: Prokineticins are a group of peptides which play important roles in angiogenesis, hematopoiesis and reproduction. Prokineticin 1 (PROK1) is reported to be the major subgroup affecting the female reproductive development. PROK1 is secreted from the syncytiotrophoblasts and it prevents extravillous trophoblastic cell migration in the first trimester which predispose to the abnormal placentation and preeclampsia (PE). Hypoxia provokes the expression of PROK1 therefore its serum levels increase in pregnants with PE. The aim of the present study was to reveal the value of PROK1 as a marker of PE. Materials and Method: A total of 84 pregnant women were admitted to the study, and 43 of them were diagnosed with preeclampsia. 41 healthy pregnant women were included in the control group. The preeclampsia group was divided into two subgroups as mild PE (n=27) and severe PE (n=16). About 10 ml of venous blood was collected from each participant and dispensed into lithium heparin, and serum was obtained, which were stored at – 80 c until analyzed. Serum PROK1 measurements were performed by using an enzyme-linked immunosorbent assay (ELİSA). All tests were two-tailed, and p

Keywords:

preeclampsia, prokinetcin 1, predictor,

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