Şenol DANE, Teoman ERDEM, Vedat ERTUNÇ, Lalenur DANE

Serum immunoglobulins and complement levels in patients with atopic dermatitis

Bu çalışmada, atopik dermatitde immünolojik faktörlerin patolojik rolünün araştırmak için, serum immunoglobulin ve kompleman seviyeleri ve bu parametrelerin atopik dermatitin şiddet skoru (scorad indeksi) arasındaki korelasyonlar araştırıldı. Atopik dermatitli hastalar ile kontroller arasında serum IgA, IgM, IgE ve C4 seviyeleri açısından fark bulunmadı. Fakat C3 ve IgG seviyeleri hastalarda düşük idi. Scorad indeksi ile serum IgG, IgM, IgE seviyeleri arasında korelasyon yoktu, fakat scorad indeksi ile IgA ve C3 seviyeleri arasında negatif korelasyonlar ve scorad indeksi ile serum C4 seviyesi arasında pozitif korelasyon bulundu. Bu bulgular gösterirkı immünoglobulinler ve kompleman sistemi atopik dermatitdeki inflamatuar proseste yer almaktadır.

Atopik dermatitli hastalarda serum immunoglobulin ve komplement düzeyleri

In this study, to research the pathological role of' immunological changes in a topic dermatitis, we investigated the serum immunoglobulins ana complement levels and the correlations between severity scoring of atopic dermatitis (scorad index) and these parameters. There was no statistically significant difference in the serum IgA, IgM, IgE, and C4 levels between the patients with atopic dermatitis and controls. But, the serum C3 and IgG levels was significantly lower in the patients than in controls. There was no correlation between scorad index and the serum IgG, IgM, and IgE levels, but the negative correlation between scorad index and the serum IgA ana C3 levels and positive correlation between scorad index and the serum Q levels. This findings suggest that immunoglobulins and complement system participates in inflammatory process in atopic dermatitis.

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