Mahmut KOPARAL, Belgin GULSUN, Derya Toprak GUNDUZ, Haluk Yener UNSAL, Halil Ibrahim ERDOGDU, Hilal ALAN

Human papilloma virus

İnsan Papilloma Virüsü (HPV) papillomaviridae ailesinden çift sarmal yapıya sahip bir DNA virüsüdür. HPV epidermisin ve mukoz membranın çok katlı yassı epitelinde benign ve malign değişikliklere neden olur. HPV baş, boyun, ürogenital organlar, deri ve mukoz membranlarda görülen birçok benign ve malign lezyonların etyolojik faktörleri arasında gösterilmektedir. HPV'nin baş boyun bölgesinde gözlenenskuamöz hücreli karsinomanın patogenezinde rol aldığı ilk olarak 1983 yılında oral kanser ve HPV enfeksiyonu arasındaki benzerlik gösterildikten sonra anlaşıldı. Oral skuamöz hücreli karsinomada etiyolojik faktör olduğu için HPV enfeksiyonu orofarengeal bölge ile ilişkili kanserlerin bir alt grubu olarak ele alınabilir. Bu özellikleri nedeniyle Maksillofasiyal Cerrahinin ve Diş Hekimliğinin yakın ilgi alanına girmiştir. Birçok HPV ile iliskili enfeksiyonda özellikle tarama, oral bulgular, erken teshis ve tedavi büyük öneme sahiptir

İnsan papilloma virüsü

Human papillomavirus (HPV) is a double-helix DNA virus in the papillomaviridae family. HPV has an affinity for epithelial tissue and causes benign and malignant changes to the stratified epithelium of the epidermis and mucous membranes. HPV is an etiological factor in many benign and malignant lesions of the head, neck, urogenital organs, skin, and mucous membranes. The role of HPV in the pathogenicity of squamous cell carcinoma in the head and neck area was first recognised in 1983 after findings showed histopathologic similarities between oral cancer and HPV infection. Because HPV has been implicated as the etiological factor for oral squamous cell carcinoma, HPV infection can be regarded as a subgroup of cancers affecting the oropharyngeal region. Due to these characteristics, HPV infection has been of particular interest in the field of maxillofacial surgery and dentistry. Screening, oral findings, early diagnosis, and proper treatment are of paramount importance in many HPVrelated infections

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