Nilgün SEREMET KÜRKLÜ, Aylin AYAZ

D Vitamini Ve Gestasyonel Diyabet

Gestasyonel diabetes mellitus (GDM), gebelik esnasında gelişen β hücre disfonksiyonu ve insülin direnci olarak tanımlanır. Gestasyonel diyabet, anne ve fetusta bir çok komplikasyona neden olabilmektedir. Normoglisemi sağlanamamış gestasyonel diyabetli kadınlar sezaryan doğum ve ileriki yaşamlarında tip 2 diyabet gelişimi riskine sahip olurken, çocuklarda ise fetal makrozomi, omuz distosisi, konjenital anomali, neonatal mortalite, hipoglisemi ve ilerleyen yaşlarda obezite ve tip 2 Diyabet görülme riski yüksektir. Literatürde, gebelerde D vitamini eksikliğinin sık görüldüğü belirtilmektedir. Gebelik döneminde D vitamini yetersizliğinin yenidoğan ve bebeklik dönemindeki D vitamini eksikliği için en önemli risk faktörü olduğu bilinmektedir. Bu nedenle de maternal D vitamini eksikliğinin neonatal hipokalsemi, kemik yoğunluğunun azalması ve rikets riskinin ortaya çıkmasına neden olmasının yanı sıra, annede sezaryan doğum, preeklempsi riskini arttırmaktadır. Gebelerde D vitamini ve gestasyonel diyabet arasındaki ilişkiyi gösteren az sayıda çalışma mevcut iken sonuçları çelişkilidir. Bu derlemede gestasyonel diyabet ve D vitamini arasındaki ilişkinin değerlendirilmesi amaçlanmaktadır.

Anahtar Kelimeler:

D vitamini, Gestasyonel Diyabet, Gebelik, Maternal D Vitamin

Vitamin D And Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is described as B cell dysfunction and insulin resistance during pregnancy. Gestational diabetes can cause important complications for mother and fetus. Women with gestational diabetes has not been achieved normoglycaemia having a risk for cesarean delivery and the development of type 2 diabetes in later life; fetal chromosomes, shoulder dystocia, congenital malformations, neonatal mortality, hypoglycemia, and advancing age, obesity and type 2 diabetes risk seen are high in children. In the literature, vitamin D deficiency is common in pregnant women is stated. Vitamin D deficiency during pregnancy is the most important risk factor for vitamin D deficiency of newborn and infancy, therefore, maternal vitamin D deficiency causues neonatal hypocalcemia, bone density decreases and the emergence of rickets risk , as well as maternal cesarean delivery and preeclampsia risk increases. There were few studies demonstrating the relationship between vitamin D and gestational diabetes in pregnant women, while results are conflicting. In this review, aimed to evaluate the relationship between gestational diabetes and vitamin D.

Keywords:

Vitamin D, Gestational Diabetes Mellitus, Pregnancy, Maternal Vitamin D,

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