Akın Eraslan BALCI, MUHARREM ÇAKMAK, Suna POLATOĞLU, Siyami AYDIN, Adile Ferda DAĞLI, Özlem ÜÇER

Göğüs Duvarında Dermatofibrosarkoma Protuberans: Olgu Sunumu

Dermatofibrosarkom protüberans nadir görülen lokal, agresif bir tümördür. Küçük boyutlu başlayıp cilt, cilt altı, kas ve kemiğe infiltre olabilir. Tanı, fizik muayene, manyetik rezonans görüntüleme ve bilgisayarlı tomografi ile konur. Tedavisi geniş güvenlik sınırları içeren cerrahi rezeksiyondur. Çalışmamızda, göğüs duvarında nadir görülen dermatofibrosarkom protuberans olgusunu paylaşmayı amaçladık.

Dermatofibrosarcoma Protuberans on Chest Wall: Case Report

Dermatofibrosarcoma protuberans is a rare, locally aggressive tumor. Inception may be small in size and can infiltrate to skin, subcutaneous tissue, muscle and bones. Diagnosis is made by physical examination, magnetic resonance imaging and computed tomography. The treatment is surgical resection with extensive safety margin. In our study, we aimed to share a rare dermatofibrosarcoma protuberance case on the chest wall.

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Fiore M, Miceli R, Mussi C, Lo Vullo S, Mariani L, Lozza L, et al. Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. J Clin Oncol 2005; 23: 7669-75.
Kransdorf MJ, Meis Kindblom JM. Dermatofibrosarcoma protuberans: radiologic appearance. AJR Am J Roentgenol 1994; 163: 391-4.
Turgut AT, Koşar U, Ergeneci A, Çakmak H. Lokal rekürens bulunmaksızın akciğer metastazı gösteren dermatofibrosarkom protüberans. Türk Tanısal ve Girişimsel Radyoloji Dergisi 2003; 9: 195-8.
Dimitropoulos VA. Dermatofibrosarcoma protuberans. Dermatol Ther 2008; 21: 428-32.
Simon MP, Pedeutour F, Sirvent N, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 1997; 15: 95-8.
McArthur G. Molecularly targeted treatment for dermatofibrosarcoma protuberans. Semin Oncol 2004; 31: 30-6.
Shimizu A, O'Brien KP, Sjoblom T, et al. The dermatofibrosarcoma protuberans-associated collagen type I alpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res 1999; 59: 3719-23.
Ruiz Tovar J, Fernández Guarino M, Reguero Callejas ME, Aguilera Velardo A, Arano Bermejo J, Cabañas Navarro L. Dermatofibrosarcoma protuberans: review of 20-years experience. Clin Transl Oncol 2006; 8: 606-10.
Patil PK, Patel SG, Krishnamurthy S, Mistry RC, Deshpande RK, Desai PB. Dermatofibrosarcoma protuberans metastatic to the lung. A case report. Tumori 1992; 78: 49-51.
Murphy SJ. Dermatofibrosarcoma protuberans: Early recognition and treatment. Am Fam Physician 2000; 62: 1257-8.
Kimmel Z, Ratner D, Kim JY, Wayne JD, Rademaker AW, Alam M. Peripheral excision margins for dermatofibrosarcoma protuberans: a metaanalysis of spatial data. Ann Surg Oncol 2007; 14: 2113-20.
Uysal B, Sager O, Gamsiz H, Cicek A, Demiral S, Dincoglan F, et al. Evaluation of the role of radiotherapy in the management of dermatofibrosarcoma protuberans. J BUON 2013; 18: 268-73.