Fatih Serhat EROL, Mehmet Birol ÖZTÜRK, BEKİR AKGÜN, METİN KAPLAN, Hakan ÇAKIN, Necip İLHAN, Selami SERHATLİOĞLU

Correlation between findings of cranial tomography and the levels of cerebrospinal fluid’s nerve growth factor in hydrocephalic infants

Amaç: Ventriküloperitoneal şant uygulanan hidrosefalili bebeklerin ameliyat öncesi ve sonrası değerlendirilmelerinde Beyin Omurilik Sıvısı Sinir Büyüme Faktörü (BOS NGF) düzeyleri ve beyin tomografisi endeksleri arasındaki ilişkiyi araştırmak. Gereç ve Yöntem: Toplam 27 hasta dahil edildi. BT incelemeleri yapıldı ve BOS örnekleri ameliyat sırasında ve ameliyat sonrası 3. ve 30. günlerde alındı. Bulgular: Spearman korelasyonu ile Bilgisayarlı beyin tomografisi (BBT) endekslerinde ve BOS NGF düzeyleri arasında korelasyon bulunamadı. Ameliyat sonrası 3. gün, NGF düzeyi ameliyat öncesi düzeylerine göre anlamlı olarak yüksek bulundu ( p

Hidrosefalik infantlarda kranial tomografi bulguları ve beyin omurilik sıvısı sinir büyüme faktörü arasındaki ilişki

Objective: To investigate the correlation between the NGF levels in the CSF and brain tomography indexes in preoperative and postoperative evalua- tions of hydrocephalic infants undergoing ventriculoperitoneal shunt. Material and Method: A total of 27 patients were included. CSF samples were obtained in the during the operation and on the 3rd and 30th postope- rative days, and CT evaluations were performed. Results: No correlation was found between the NGF levels in CSF and CCT indexes using the Spearman correlation. The increases of NGF levels on the 3rd postoperative day were significantly higher than those of the peroperative levels (p<0.05). While the decrease was significant between the levels of NGF on the 30th and the 3rd postoperative days (p<0.05), the difference was not significant between the levels on the 30th postoperative day and the levels in the peroperative period (p>0.05),(0,023/0,015). The differences between the postoperative 3rd and 30th days were significant accor- ding to Evan’s indexes, 3th ventricle indexes and ventricular scores (p<0.05). It was found that there was no significant difference between Sella media indexes in the preoperative period and on the postoperative 3rd day (p>0.05), (0,48/0,44), but that there was significant decrease on the 30th postoperative day (p<0.05). Conclusion: Conclusions:There was no significant correlation between NGF levels of CSF and brain tomography indexes in the preoperative and postoperative evaluation of infants with hydrocephaly. However, significant relationship was seen within each parameter. The NGF levels of CSF and cranial tomography indexes can be helpful in the diagnosis, treatment and follow-up of hydrocephalus.

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