Türkiye'de Geranium Macrorrhizum L. (Geraniaceae) Metanol Ekstresinin Biyolojik ve Antimikrobiyal Aktivitesinin Belirlenmesi

Dünyanın değişik bölgelerinde Geranium türleri, ağrı kesici, kan dindirici, antihemoroidal, antidiyabetik, ateş düşürücü, antidiyareik, kan temizleyici ve gastrointestinal sistem rahatsızlıklarının tedavisinde kullanılmaktadır. Bu çalışma da Balıkesir ili’nden toplanan Geranium macrorrhizum türünün metanol ekstresinde biyolojik ve antimikrobiyal aktivite çalışmaları yapılmıştır. “Geranium macrorrhizum metanol ekstresinde”, numunenin toplam fenolik içerik miktarı 130.18 µg GAE / 1g kuru örnek olarak bulunmuştur. Geranium macrorrhizum metanol ekstresinde, toplam flavonoid içerik miktarı 55,56 ± 1,20 mg QE/g kuru numune olarak belirlenmiştir. Geranium macrorrhizum (Geraniaceae)’nın metanol ekstresinde ABTS radikal giderme aktivitesi 5.80 ± 0,55 lC50 (μg/mL) olarak bulunmuştur. DPPH radikali olarak antioksidan aktivitesi 10,05 μg/mL olarak belirlenmiştir. Geranium macrorrhizum metanol ekstresi için en duyarlı bakterinin Klebsiella pneumoniae ATCC700603 (13 mm) olduğu tespit edilmiştir. Elde edilen bulgular Geranium macrorrhizum bitkisinin tıbbi bitki olarak değerlendirilebileceğini göstermektedir. İleri araştırmalarda G. macrorrhizum’un içerdiği kimyasal bileşenlerin belirlenmesinin yanı sıra in situ ve in vivo testler ile etki mekanizmalarının daha detaylı araştırılmasının gerekli olduğu sonucuna varılmıştır.

Anahtar Kelimeler:

Geranium macrorrhizum, Geraniaceae, Toplam Fenolik İçerik

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