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HPLC ile Enjeksiyon Çözeltilerde Vitamin K3-Amprolyum HCl-Metilparaben-Propilparaben Miktar Tayini

Bu çalışmada antiprotozoal etkili amprolyum HCl, kanın pıhtılaşmasını önleme açısından etkili vitamin K3, antimikrobiyal koruyucu etkili metilparaben ve propilparabeni bir arada içeren oral enjeksiyon çözeltisinin zaman açısından avantajı nedeniyle tek bir HPLC yöntemi ile miktar tayini ve validasyon çalışmaları yapılmıştır. Analizlerde 25°C'de İnertsil C8-3 4,6 x 250 mm, 5 µm kolon, 254nm’de dalga boyunda heptan-1-sülfonik asit sodyum tuzu, glasiyel asetik asit, trietilamin tampon çözeltisi ve asetonitril ve metanol kullanılmıştır. Seçicilik, sistem uygunluk, doğrusallık ve doğruluk parametreleri çalışılmış ve kabul edilebilir sonuçlar elde edilmiştir.

Anahtar Kelimeler:

Vitamin K3, Amprolyum HCl, Metilparaben, Propilparaben, HPLC

Quantitative HPLC Analysis of Vitamin K3-Amprolium HCl-Methylparaben-Propylparaben in Oral Solutions

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