AYŞEGÜL DOĞAN DEMİR, UFUK ERENBERK, İlker Tolga ÖZGEN, Emin ÖZKAYA, Aysel TÜRKMEN VAHAPOĞLU, M. Ruşen DÜNDARÖZ, Özcan EREL

Total antioxidant and oxidant status in obese children without insulin resistance

Amaç: Obez çocuklardaki oksidatif stres, erişkin dönemde koroner kalp hastalıkları veya tip 2 diyabet gibi ciddi durumlara öncülük edebilir. Çocukluktaki oksidatif stres insülin direnci veya ileri derece obezite ile ilişkilidir. Biz bu çalışmada, insulin direnci olmayan orta düzeyde obez çocuklarda oksidatif stres durumunu değerlendirmeyi amaçladık. Yöntemler: İnsülin direnci olmayan 38 obez çocuk (21 erkek,17 kız, ortalama yaş 9,4±3,8 yıl) ve kontrol grubu olarak 51 normal ağırlıklı çocuk (25 erkek, 26 kız, ortalama yaş 9,3±3,9 yıl) çalışmaya alındı. Total oksidatif durum (TOD), total antioksidan kapasite (TAK) ölçüldü ve oksidatif stres indeksi (OSİ) hesaplandı. Bulgular: Sonuçlar obez çocukların normal ağırlıklı çocuklardan daha düşük TAKa sahip olduğunu ortaya koydu (2,27±0,28 ve 2,76±0,35 mmol Trolox Eq./L; p

İnsülin direnci olmayan obez çocuklarda total antioksidan ve oksidanların durumu

Objective: Oxidative stress in obese children may lead in adulthood serious conditions such as coronary heart diseases or type 2 diabetes mellitus. In childhood oxidative stress is associated with insulin resistance or extreme obesity. In this study, we aimed to evaluate oxidative stress status in moderately obese children without insulin resistance. Methods: A total of 38 obese children (21 male, 17 female) without insulin resistance, mean aged 9.4±3.8 years) and 51 normal weight children (25 male, 26 female) as the control group, mean aged 9.3±3.9 years) were enrolled to the study. Total oxidative status (TOS), total antioxidant capacity (TAC) were measured and oxidative stress index (OSI) was calculated. Results: The results reveal that obese children had lower TAC than normal weight children (2,27±0,28 vs. 2.76±0.35 mmol Trolox Eq./L; p<0,001). There was no statistical difference between obese and control groups regarding TOS (6,08±3,63 vs 5.25±4.16 μmol H2 O2 Eq./L; p=0.333). OSI was higher in obese group (2.65±1.52 vs 1.92±1.56; p=0.029) Conclusion: Balance between oxidant and antioxidant system is disrupted due to the reduced TAC even in moderately obese children without insulin resistance. Further studies should also be performed to evaluate the beneficial effects of dietary intake of antioxidants in these children.

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