Terapötik potansiyele sahip venom peptidleri

Farmazootikler doğal kaynaklardan elde edilen az sayıdaki ilacı tanımlamada kullanılan bir terimdir. Söz konusu doğal kaynaklar bitkiler ve zehirli yılan, akrep, örümcek, kurbağa, kertenkele ve deniz canlısı türleri olarak sayılabilirler. Zehirin peptid yapılı bileşenleri iyon kanalları ve reseptörler gibi çeşitli farmakolojik hedefler üzerinden etkilerini gösterirler. Bu tarz etkilerinden dolayı zehir bileşimindeki peptidler başlangıçta, memeliler gibi organizmaların fizyolojik, biyokimyasal ve immünolojik faaliyetlerinin tanımlanmasında kullanılmıştır. Son dönemde yapılan çalışmalarda peptid bileşenlerinin otoimmün, kronik enflamatuar, kardiyovasküler, nörolojik ve tümöral hastalıkların tedavisinde de etkili olabildiği gösterilmiştir. Bu bakımdan özellikle klinik uygulamalarda venom peptidlerine ya da sentetik türevlerine, gösterdikleri yüksek potensin yanında düşük yan etki potansiyellerinden dolayı günümüzün klasik ilaçlarının yerini alacakları gözüyle bakılmaktadır.

Anahtar Kelimeler:

Peptidler, Zehirler

Therapeutical potential of venom peptides

The term of pharmazooticals is known as a few amount of drugs derived from natural sources such as plants, venomous species of snakes, spiders, scorpions, frogs, lizards and cone snails. Peptide components of venoms are directed against wide variety of pharmacological targets such as ion channels and receptors. At the beginning, a number of these peptides have been used in experimental studies for defining the physiological, biochemical and immunological activities of organisms like mammalians. In recent studies, it has been shown that venom peptides can be valuable in treatment of acute and chronic pain, autoimmune and cardiovascular diseases, neurological disorders and chronic inflammatory and tumoral processes. Therefore particularly in clinical approaches, these peptide molecules or their synthetic analogues are considered as alternative agents that can be used instead of classical drugs for many clinical disorders due to their potent activity besides very few side effects.

Keywords:

Peptides, Venoms,

PDF

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1. Skarnulis L, Nazario B. Wonder drugs using pharmazooticals. WebMD Inc., 2003 Aug.http://www.webmd.com/content/article/78 /95687.htm
2. Lewis RJ, Garcia ML. Therapeutic potential of venom peptides. Nature reviews. Drug discovery., 2003;2:790-802. http://www.imb.uq.edu.au/download/large/Veno m_therapeutics.pdf
3. Albers T. Micro-screening of venoms. 2002 July:28. http://www.venomstodrugs.com/Venoms_Abstra ct_book.pdf
4. Ely T. Conotoxins reveal significant psychopharmacological effectiveness: the future of pain management. Journal of Psychology and Behavioral Sciences, 2003; 17: 18 http://www.alpha.fdu.edu/psychweb/Vol16- 17/Ely_Proof.pdf
5. From bites and stings to medicines. http://www.chemsoc.org/chembytes/ezine/199 9/berressem_apr99.htm
6. Lewis RJ, Nielsen C, Ross F, Drinkwater R, Alewood P, Smith M. Therapeutic potential of ω- and χ-conotoxins. 2002 July:34. http://www.venomstodrugs.com/Venoms_Abst ract_book.pdf
7. http://www.neuro.wustl.edu/neuromuscu lar/mother/chan.html
8. http://www.nature.com/bjp/journal/v144/ n1s/pdf/0706161a.pdf
9.Craik DJ, Clark R, Daly NL. Circular protein toxins – no end(s) in sight. 2002 July:11. http://www.venomstodrugs.com/Venoms_Abst ract_book.pdf
10. http://www.cyclotide.com/what.html
11. Browne DL, Gancher ST, Nutt JG, et al. Episodic ataxia / myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat Genet. 1994;8:136-140.
12. Adelman JP, Bond CT, Pessia M, Maylie J. Episodic ataxia results from voltagedependent potassium channels with altered functions. Neuron. 1995;15:1449-1454.
13. Wulff H, Calabresi PA, Yun S, et al. Blockade of Kv1.3 channels in myeline reactive T cells as a therapeutic target for multiple sclerosis. 2002:33.
14. Effective new autoimmune disease drugs to use scorpion venom. http://thyroid.about.com/library/weekly/aa0718 00a.htm
15. Swenson S, Costa F, Minea R, et al. Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression. Mol Cancer Ther. 2004;3:499-511
16. Highfield R. Snake’s venom may help treat breast cancer. http://arachnophiliac.co.uk/burrow/news/snakes_venom_and_breast_cancer.htm
17. Scorpion venom might help in brain cancer – study. http://naturalhealthline.com/newsletter/HL 990201/venom.htm
18. Maruo VM, Lebrun I, Dorce VAC. Effects of scorpion Tityus serrulatus venom toxin TS-8F on rat learning and memory. J. Venom. Anim. Toxins, 2002; 8:74-87.
19. http://www.ihop-net.org/UniPub/iHOP /gs /92088.html
20. Tytgat J. Antibacterial and antifungal peptides in scorpion venom: an emerging class of novel therapeutics. 2002 July:22. http://www.venomstodrugs.com/Venoms_ Abstract_book.pdf
21. http://www.histemb.medicine.ankara.e du.tr/Hücre_Hücre_Hücre_Matriks_İlişki.pdf
22. http://www.scripps.edu/bcmd/pdfarea/i ssue_12_97/zanetti.pdf
23. D'Souza SE, Ginsberg MH, Plow EF. Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif. Trends Biochem Sci. 1991;16:246-250.
24. Gulick AM, Hubbard BK, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. Biochemistry. 2000 Apr 25;39:4590- 4602.
25. http://nic.sav.sk/logos/books/scientific/ node29.html
26. http://lokman.cu.edu.tr/anestezi/aneste zinot/yogun.htm
27. http://www.indstate.edu/thcme/mwkin g/blood-coagulation.html
28. http://www.haemtech.com/Cofactors/F actor_Va.htm
29. http://www.labtestsonline.org/images/c oag_cascade.pdf
30. Schöni R, Stocker C, Rudin K, Bühler B, Wilmer M. Snake venom components as esential tools for new diagnostic test kits in hematology. 2002 July:52. http://www.venomstodrugs.com/Venoms_Abst ract_book.pdf
31. Kini RM, Jacob B, Joseph JS. Development of novel class of anticoagulant peptides based on the structure of prothrombin activator from Tropidechis carinatus venom. 2002 July:17. http://www.venomstodrugs.com/Venoms_Abst ract_book.pdf
32. http://www.geocities.com/mammalia2000/taf.html
33. http://www.reptile.fisek.com.tr/indexy. htm
34. http://www.emblheidelberg.de/~uetz/families/taxa.html#ser
35. http://www.faunaeur.org/fullresults.php?id=15446
36. http://www1.gantep.edu.tr/~Varol/tr/as il-tr.htm