BANU AYDIN, Dilek DİLLİ, Ayşegül ZENCİROĞLU, Derya ERDOĞAN, İBRAHİM KARAMAN, Mehmet Şah İPEK, Nurullah OKUMUŞ

Intussusception in a term newborn with duct-dependent congenital heart disease

Prostaglandin E1 infüzyonu, duktus bağımlı konjenital kalp hastalığı olan yenidoğanlarda ameliyat edilinceye kadar duktusu açık tutmak amacıyla yaygın olarak kul- lanılmaktadır. Prostaglandin E1 yaşam kurtarıcı bir ilactır ancak ateş, apne, bradikardi, hipotansiyon, konvülziyon, ödem ve kortikal hiperostoz gibi birçok yan etkiye de yol açabilir. İlacın doz azaltmasına yanıt veren ishal dışında gastrointestinal sistemle ilgili önemli yan etkisi rapor edilmemektedir. Bu yazıda duktus bağımlı konjenital kalp hastalığı olan ve olasılıkla prostaglandin tedavisi ile tetiklenen intestinal invajinasyon gelişen bir olgu sunuldu.

Duktus bağımlı konjenital kalp hastalığı olan bir term yenidoğanda invajinasyon

Prostaglandin E1 infusion is widely used to maintain pa- tency of ductus arteriosus in newborns with duct-depen- dent congenital heart disease until surgery. Prostaglandin E1 is a lifesaving drug, but it has many side effects includ- ing fever, apnea, bradycardia, hypotension, convulsion, edema, and cortical hyperostosis. The gastrointestinal tract has not been recognized as a major site of serious adverse effects of prostaglandin E1 infusion, although diarrhea is a well-recognized side effect that usually re- sponds to dose reduction. In this report, we present a case of intestinal intussusception presumably induced by prostaglandin therapy in a newborn with duct-dependent congenital heart disease.

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