Nuray CAN USTA, Vildan ALTUNAYOĞLU ÇAKMAK, İsmet DURMUS, Murat TOPBAŞ, Zeynep KAZAZ, Oguzhan Ekrem TURAN

Huzursuz bacaklar sendromlu hastalarda kalp hızı değişkenliği ve ritim analizi: Bir prospektif olgu-kontrol çalışması

Amaç: Kalp hızı değişkenliği (KHD) analizi ile huzursuz bacaklar sendromu (HBS) hastalarında kardiyak otonomik tutulumu araştırmak. Yöntemler: Prospektif olgu-kontrol çalışması tipindeki bu çalışmaya HBS hastaları ve yaş/cinsiyet uyumlu sağlıklı kontroller dahil edildi. HBS tanısı Uluslararası Huzursuz Bacaklar Sendromu Çalışma Grubu tarafından belirlenen kriterlere göre konuldu. Demografik veriler ve hastalığın şiddeti kayıt edildi. Tüm hasta ve kontrol gruplarında 24 saatlik elektrokardiyografik Holter monitörizasyonu ile HRV analizi yapıldı. Bulgular: Çalışma grubunda 65 (50 kadın), kontrol grubunda 58 (45 kadın) hasta mevcuttu. Hastalar ve kontrol grupları yaş ve cinsiyet açısından benzerdi. HRV analizinde HBS hastaları ve kontrol grubu karşılaştırıldığında SDNN gece değerinin düşük olması dışında fark bulunmadı (p=0,03). KHD analizleri hastalık şiddetine göre karşılaştırıldığında SDNN gece değeri gruplar arasında anlamlı farklılık gösterdi (p=0,03). İkili karşılaştırmada şiddetli ve çok şiddetli gruplar arasındaki fark anlamlıydı (p=0,01) ve şiddetli grup, çok şiddetli gruba göre daha düşüktü. Sonuç: HBS'li hastalarda HRV ile kardiyak otonom sistemi değerlendiren bu çalışmada, gece saatlerinde parasempatik sinir sistemininde azalma saptanmıştır.

Anahtar Kelimeler:

Huzursuz Bacaklar Sendromu, Kalp Hızı Değişkenliği, Otonomik Disfonksiyon

Heart rate variability and analysis of rhythm in patients with restless legs syndrome: A prospective case-control study

Aim: To investigate the involvement of cardiac autonomy by heart rate variability (HRV) analysis in patients with restless legs syndrome (RLS). Methods: Patients with RLS and age/sex matched healthy controls were included in this prospective case-control study. The diagnosis of RLS was made according to the criteria determined by the International Restless Legs Syndrome Study Group. Demographic data and severity of disease were recorded. The HRV analysis was performed with a 24-hour electrocardiographic Holter monitoring in all patients and the control group. Results: Sixty five (50 female) patients and 58 (45 female) healthy individuals were enrolled into the study. Patients and control groups were similar for age and gender. No difference was found in the HRV analysis, except that the standard deviation of NN intervals (SDNN) at night was lower when RLS patients and the control group were compared (p=0.03). The HRV analyzes were compared according to disease severity, SDNN at night was significantly different between groups (p=0.03). In the pairwise comparison, the difference between the severe and very severe groups was significant (p=0.01) and severe group was lower than very severe group. Conclusions: In the present study which evaluate the cardiac autonomic system with HRV in patients with RLS, a decrease in parasympathetic nervous system was found at night time.

Keywords:

Restless Legs Syndrome, Heart Rate Variability, Autonomic Disfonction,

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