FARKLI HASTANELERDEN İZOLE EDİLEN ACİNETOBACTER BAUMANNİİ SUŞLARININ GENETİK ÇEŞİTLİLİĞİ

Amaç: Suşların genotipik analizi, suşlar arasındaki genetik ilişkileri ve epidemiyolojik araştırmaları değerlendirmek için bilgi sağlayabilir ve farklı coğrafi bölgelerdeki dolaşımlarının izlenmesi için önemlidir. Bu çalışma, dört farklı hastaneden elde edilen klinik Acinetobacter baumannii (A. baumannii) izolatları arasındaki genetik benzerlik veya farklılıkları belirlemeyi amaçlamıştır.

GENETIC DIVERSITY OF ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM DIFFERENT HOSPITALS

Objective: The genotypic analysis of the strains can provide information to evaluate the genetic relationships among strains and epidemiological investigations, and it is crucial for monitoring their circulation in different geographic regions. This study was to aim to identify genetic similarities or dissimilarities among clinical Acinetobacter baumannii (A. baumannii) isolates from four different hospitals.

___

  • 1. Vincent, J.L., Rello, J., Marshall, J., Silva, E., Anzueto, A., Martin, C.D., Reinhart, K. (2009). International study of the prevalence and outcomes of infection in intensive care units. Jama, 302(21), 2323-2329. [CrossRef]
  • 2. Roca, I., Espinal, P., Vila-Farrés, X., Vila, J. (2012). The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace. Frontiers in Microbiology, 3, 148-169. [CrossRef]
  • 3. Kiyasu, Y., Hitomi, S., Funayama, Y., Saito, K., Ishikawa, H. (2020). Characteristics of invasive Acinetobacter infection: A multicenter investigation with molecular identification of causative organisms. Journal of Infection and Chemotherapy, 26(5), 475-482. [CrossRef]
  • 4. Lima, W.G., Alves, M.C., Cruz, W.S., Paiva, M.C. (2018). Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat. European Journal of Clinical Microbiology and Infectious Diseases, 37(6), 1009-1019. [CrossRef]
  • 5. An, J.H., Kim, Y.H., Moon, J.E., Jeong, J.H., Kim, S.H., Kang, S.J., Jang, H.C. (2017). Active surveillance for carbapenem-resistant Acinetobacter baumannii in a medical intensive care unit: Can it predict and reduce subsequent infections and the use of colistin?. American Journal of Infection Control, 45(6), 667-672. [CrossRef]
  • 6. Antunes, L.C., Visca, P., Towner, K.J. (2014). Acinetobacter baumannii: evolution of a global pathogen. Pathogens and Disease, 71(3), 292-301. [CrossRef]
  • 7. Maleki, A., Vandyousefi, J., Mirzaie, Z., Ghafourian, S., Kazemian, H., Sadeghifard, N. (2017). Molecular Analysis of the Isolates of Acinetobacter baumannii isolated from Tehran Hospitals Using ERIC-PCR Method. Modern Medical Laboratory Journal, 1(1), 12-16. [CrossRef]
  • 8. Aljindan, R., Alsamman, K., Elhadi, N. (2018). ERIC-PCR genotyping of Acinetobacter baumannii isolated from different clinical specimens. Saudi Journal of Medicine and Medical Sciences, 6(1), 13-17. [CrossRef]
  • 9. Testing EUCAST (2016). EUCAST disk diffusion test manual, version 4.0. [CrossRef]
  • 10. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0, valid from 2020-01-01. Basel, Switzerland: EUCAST [accessed 15 Mart 2020].
  • 11. Dorneles, E.M., Santana, J.A., Ribeiro, D., Dorella, F.A., Guimaraes, A.S., Moawad, M.S., Lage, A.P. (2014). Evaluation of ERIC-PCR as genotyping method for Corynebacterium pseudotuberculosis isolates. PLoS One, 9(6), e98758. [CrossRef]
  • 12. McConnell, M.J., Actis, L., Pachon, J. (2013). Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. FEMS Microbiol Review, 37(2), 130-155. [CrossRef]
  • 13. Fishbain, J., Peleg, A.Y. (2010). Treatment of Acinetobacter infections. Clinical Infectious Diseases, 51(1), 79-84. [CrossRef]
  • 14. Karaoglan, I., Zer, Y., Bosnak, V.K., Mete, A.O., Namiduru, M. (2013). In vitro synergistic activity of colistin with tigecycline or beta-lactam antibiotic/beta-lactamase inhibitor combinations against carbapenem-resistant Acinetobacter baumannii. Journal of International Medical Research, 41(6), 1830-1837. [CrossRef]
  • 15. Principe, L., D'Arezzo, S., Capone, A., Petrosillo, N., Visca, P. (2009). In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii. Annals of Clinical Microbiology and Antimicrobials, 8, 18-29. [CrossRef]
  • 16. Zarifi, E., Ghazalibina, M., Mansouri, S., Morshedi, K., Pourmajed, R., Arfaatabar, M. (2020). Molecular typing of Acinetobacter baumannii clinical strains by enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR). Gene Reports, 18, 100542. [CrossRef]
  • 17. Hazhirkamal, M., Zarei, O., Movahedi, M., Karami, P., Shokoohizadeh, L., Taheri, M. (2021). Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Iran. BMC pharmacology and toxicology, 22(1), 32-32. [CrossRef]
  • 18. Falah, F., Shokoohizadeh, L., Adabi, M. (2019). Molecular identification and genotyping of Acinetobacter baumannii isolated from burn patients by PCR and ERIC-PCR. Scars, Burns and Healing, 5, 2059513119831369. [CrossRef]
  • 19. Gautam, H., Maheshwari, B., Mohapatra, S., Sood, S., Dhawan, B., Kapil, A., Tezpur, B. (2022). Clonal relationship among Acinetobacter baumannii isolates from different clinical specimens by ERIC-PCR. International Journal of Infectious Diseases, 116, S18-S19. [CrossRef]
  • 20. Lotfi, F., Shojaie, M., Rahbarnia, L., Dehnad, A., Naghili, B., Lotfi, H. (2022). Molecular characterization and genetic diversity of multidrug- and extensively drug-resistant A. baumannii clinical isolates. Gene Reports, 26, 101455. [CrossRef]
Ankara Üniversitesi Eczacılık Fakültesi Dergisi-Cover
  • ISSN: 1015-3918
  • Yayın Aralığı: 3
  • Başlangıç: 2016
  • Yayıncı: Ankara Üniversitesi Eczacılık Fakültesi
Sayıdaki Diğer Makaleler

MESLEKLER ARASI EĞİTİME GENÇ BAKIŞ: SİMÜLASYON UYGULAMASINA YÖNELİK ÖĞRENCİ GÖRÜŞLERİ

Bilge SÖZEN ŞAHNE, Elif ULUTAŞ, Leyla YUMRUKAYA, Melih ELÇİN, Selen YEĞENOĞLU

REBOKSETİN’İN DİYABETİK SIÇANLARDA BOZULMUŞ DAVRANIŞ PARAMETRELERİ ÜZERİNDEKİ YARARLI ETKİLERİ

Nazlı TURAN YÜCEL, Ümmühan KANDEMİR, Umut İrfan ÜÇEL, Özgür Devrim CAN, Ümide DEMİR ÖZKAY

İNSAN AKCİĞER HÜCRELERİNDE ROUNDUP® TOKSİSİTESİNİN DEĞERLENDİRİLMESİ

Burcu ÜNLÜ ENDİRLİK, Elçin BAKIR, Aysun ÖKÇESİZ, Zuhal HAMURCU, Ayşe EKEN, Aylin GÜRBAY

POTANSİYEL FAAH İNHİBİTÖRÜ OLARAK BAZI ARİLHİDRAZON TÜREVİ BİLEŞİKLERİN TASARIMI VE SENTEZİ

Zehra Tuğçe GÜR MAZ, Sümeyye TURANLI, H. Burak CALISKAN

LEVOTİROKSİN SODYUMUN KONTROLLÜ SALIMI İÇİN IN-SITU PARENTERAL BİYOBOZUNUR İMPLANT FORMÜLASYONU VE DEĞERLENDİRİLMESİ

Manish GOYANİ, Meghraj SURYAWANSHİ, Ridhdhesh JIVAWALA

ECZACI VE ECZANE PERSONELİNDE STAPHYLOCOCCUS AUREUS BURUN TAŞIYICILIĞI

Halil BAL, Sulhiye YILDIZ

DOKSORUBİSİN İLE OLUŞTURULAN KRONİK KALP YETMEZLİĞİ MODELİNDE VE Β-ADRENERJİK BLOKERLERİN KULLANIMI SIRASINDA SIÇANLARDA BÜTÜNLEYİCİ VE BİYOKİMYASAL PARAMETRELER

Igor BELENİCHEV, Pavlo BAK, Olena POPAZOVA, Victor RYZHENKO, Nina BUKHTİYAROVA, Andrii PUZYRENKO

FARKLI HASTANELERDEN İZOLE EDİLEN ACİNETOBACTER BAUMANNİİ SUŞLARININ GENETİK ÇEŞİTLİLİĞİ

Hilal Basak EROL, Banu KAŞKATEPE, Nurten ALTANLAR, Sulhiye YILDIZ, Süleyman YALÇIN

CLINOPODIUM PAMPHYLICUM SUBSP. DAVISII (CONTANDR. & QUÉZEL) GOVAERTS TOPRAK ÜSTÜ KISIMLARININ ANTİOKSİDAN, ENZİM İNHİBİSYON POTANSİYELİ VE FENOLİK PROFİLİNİN İNCELENMESİ

Nuraniye ERUYGUR, Fatma AYAZ

FARKLI KLİNİK ÖRNEKLERDEN İZOLE EDİLMİŞ KLEBSIELLA PNEUMONIAE İZOLATLARININ ANTİBİYOTİK DİRENÇ PROFİLİNİN İNCELENMESİ: COVID-19 PANDEMİSİ SÜRECİNDEKİ BİR YILLIK VERİLER

Derya DOĞANAY, Müzeyyen AYDIN, İbrahim Serkan AVŞAR