İlker İNCE, Elif OZCİMEN, Alparslan TURAN

Meta-Analiz: Bir Derleme

Meta-analiz, birçok çalışmadaki verileri birleştirmek ve tedavi müdahalelerinin etkinliğini değerlendirmek için sık kullanılan bir istatistiksel tekniktir. Bağımsız çalışmalardan elde edilen sonuçları birleştirerek hem çalışmanın gücünü artırabilir (bireysel çalışmalara göre) hem de effect size tahminlerini iyileştirebilir. Meta-analiz yürütme süreçleri arasında bir protokol geliştirmek, makaleler seçmek, dahil edilme kriterleri geliştirmek, veri toplamak, veri analizi yapmak ve sonuçları yorumlamak bulunmaktadır. Meta-analizin önemli bir limitasyonu, sadece analiz için geri alınabilir verilere sahip ilgili çalışmaların dahil edilebilmesidir. Bu durum publication(yayin) bias için endişe yaratmaktadir. Meta-analizin, tıp literatürünü özetlerken önemli bilgiler sağlayabilecek tam olarak faydalı bir bilimsel yöntem olduğu oldukça açıktır. Bununla birlikte, dahil edilen araştırmaların araştırma sorusuyla aynı olmadığı veya farklı sonuç verileri topladığı takdirde yanıltıcı olabilir.

Meta-Analysis: A Review Article

Meta-analysis is a frequently used statistical technique which uses to combine data from severalstudies to evaluate the effectiveness of treatment interventions. By combining results from independent studies, we can both increase power of the study (over individual studies) and improveestimates of the size of the effect. The processes of conducting meta-analysis include developinga protocol, selecting articles, developing inclusion criteria, collecting data, data analysis andinterpreting results. A major limitation of the meta-analysis is that only relevant studies whichhave retrievable data can be included for analysis. This causes concern for publication bias. It isobvious that metaanalysis is a useful scientific method that can provide important informationwhen summarizing medical literature. However, there can be misleading if the studies includedare non-similar in their research question or collect different types of outcome data.

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