Angiomyofibroblastoma of the uterine cervix in a patient with triple negative breast cancer: a case report

Angiomyofibroblastoma of the uterine cervix in a patient with triple negative breast cancer: a case report

Angiomyofibroblastoma is an uncommon, benign mesenchymal tumor which generally occurs in the vulvovaginal region. Uterine cervix localisation is uncommon. A 40-year-old female patient, who had been operated becasue of breast carcinoma, presented vaginal bleeding. Examination revealed a polypoid mass located in both vagina and cervix. She underwent total abdominal hysterectomy and bilateral salpingectomy. With the help of typical histopathology and immunohistochemical findings, a diagnosis of “angiomyofibroblastoma” was made. Angiomyofibroblastoma is a benign mesenchymal tumor of unknown pathogenesis. A recognition of this entity is important to avoid misdagnosis of other angiomyxoid neoplasms such as aggressive angiomyxoma.

___

  • Lee CL, Ng BK, Nurismah MI, Chew KT, Aruku N, Lim P. Concurrent utero-vaginal prolapse with cervical angiomyofibroblastoma : a rare disease with distinct entity. J Surg Acad 2015; 5: 58–61.
  • Min JK, Ji NK, Lindsay Ji HS, Chang Lim Hyun SSS, Chul Min Park SYK. Angiomyofibroblastoma of the uterine cervix in a breast cancer patient: A case report. Korean J Obstet 2011; 54: 330.
  • Fletcher CD, Tsang WY, Fisher C, Lee KC CJ. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol 1992; 16: 373–82.
  • Babala P, Bíró C, Klačko M, Mikloš P, Ondruš D. Angiomyofibroblastoma of the cervix uteri: a case report. Klin Onkol 2011; 24: 133–6.
  • Wong YP, Tan GC, Ng PF. Cervical angiomyofibroblastoma: a case report and review of literature. J Obstet Gynaecol (Lahore) 2017; 37: 681–2.
  • Roncati L, Pusiol T, Piscioli F, Barbolini G MA. Undetermined cervical smear due to angiomyofibroblastoma of the cervix uteri. J Obstet Gynaecol (Lahore) 2017; 37: 829–30.
  • M Varras, C Akrivis, A Demou, E Kitsiou N Antoniou. Angiomyofibroblastoma of the vagina in a postmenopausal breast cancer patient treated with tamoxifen : clinicopathologic analysis of a case and review of the literature. Int J Gynecol Cancer 2006; 581–5.
  • Weis SW GJ. Enzinger and Weiss’s Soft Tissue Tumors. 4th ed. St. Louis: Mosby. In: Enzinger and Weiss’s Soft Tissue Tumors 4th ed St Louis: Mosby 2001. p. 695–723.
  • Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynecologic soft-tissue neoplasm. Am J Surg Pathol 1983; 7: 463–75.
  • Salman MC, Kuzey GM, Dogan NU, Yuce K. Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis. Arch Gynecol Obstet 2009; 280: 485-7.
  • Laskin WB, Fetsch JF, Tavassoli FA. Myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract. Hum Pathol 2001; 32: 715–25.
  • Salman MC, Ureyen I, Tanas O, Baydar DE, Yuce K. Possible Relationship Between Tamoxifen Therapy and Vaginal Angiomyofibroblastoma. UHOD 1992; 49–52.
  • Lee H, Jang KY, Park HS, et al. Angiomyofibroblastoma of the vagina in a breast cancer patient. Pathology 2008; 40: 534–6.
  • Kumasaka T, Mitani K, Shiotsu H, Kato H, Joho M, Suda K. Vascular endothelial growth factor expressed by mast cells rather than tumour cells in angiomyofibroblastoma of the vaginal wall. Histopathology 2007; 51: 557–9.
  • Saleh MM, Yassin AH, Zaklama M. Recurrent angiomyofibroblastoma of the vagina: a case report. Eur J Gynaecol Oncol 2007; 28: 324.
Anatolian Current Medical Journal-Cover
  • Yayın Aralığı: 6
  • Başlangıç: 2019
  • Yayıncı: MediHealth Academy Yayıncılık
Sayıdaki Diğer Makaleler

Relationship between vitamin D levels and mortality rates of critically ill patients in intensive care unit

Müslüm SAĞIR, Mustafa KAPLAN, Alpaslan TANOĞLU, Fevzi DEMİREL

Local plus sedoanalgesia or spinal analgesia in endovascular aortic aneurysm repair experiences in a single center

Mevlüt DOĞUKAN, Öznur ULUDAG, Mehmet DURAN, Murat Abdulhamit ERCİŞLİ, Kıymet CEYHAN, Cengiz GÜVEN, Ayşe BAYSAL

Recurrence rates and factors affecting recurrence after traumatic anterior shoulder dislocation

Mehmet Ozbey BUYUKKUSCU, Ahmet KULDUK, Abdurrahman AYDIN, Engin ÇETİNKAYA, Şükrü Sarper GÜRSÜ

The relationship between health-related quality of life and demographic characteristics in patients with chronic hepatitis B

Handan ALAY, Sinan YILMAZ, Mehmet PARLAK, Fatma KESMEZ CAN, Nurdan PÜR

Evaluation of long-term effect of tuberculosis chemoprophylaxis in patients using anti tumor necrosis factor alpha agents

Şeyma BAŞLILAR, Mehtap AYDIN

Nosocomial infection rates of three-years in neurological intensive care unit and relationship to mortality

Nuray BİLGE, Recep YEVGİ, Mustafa CEYLAN, Emine PARLAK, Fatma ŞİMŞEK

Determination of measles, rubella, mumps and chickenpox seropositivity of district public hospital healthcare workers

Dilek YEKENKURUL

Detected frequency of bacteremia in pressure ulcer and the decision to systemic antibiotic

Hasan ÖZTİN, Mete ERDEMİR, İlyas OZTURK

Surgical nurses’ knowledge levels about hemodynamic monitoring

Esra ÖZKAN, Nurşen KULAKAÇ, Ceyda UZUN ŞAHİN, Dilek ÇİLİNGİR

Evaluation of spleen volume in thoracic computed tomography in patients with COVID-19 pneumonia

Cesur SAMANCI, Bengü ŞAYLAN, Melike YEŞİLDAL, Eyup CAMURCUOGLU, Fethi Emre USTABAŞIOĞLU