Pınar ÇİMEN, Mehmet ÜNLÜ, Cenk KIRAKLI, Semra BİLAÇEROĞLU, Recep DEMİRER

Klomipraminin indüklediği ve akut solunum yetmezliğine yol açan ilk akut eozinofilik pnömoni benzeri sendromun olgu sunumu

İlaçlar eozinofilik akciğer hastalıklarının iyi bilinen nedenlerinden olup, ilaçlarla indüklenen eozinofilik akciğer hastalıkları çok farklı klinik tablolarla ortaya çıkabilmektedir. Klinik bulgular geçici asemptomatik infiltratlardan akut solunum yetmezliğine neden olan akut eozinofilik pnömoni benzeri sendroma kadar değişkenlik gösterebilmektedir. Bu olgu sunumu, akut hipoksemik solunum yetmezliğine yol açan ve başarı ile tedavi edilebilen bugüne kadar tanımlanmış ilk klomipramine bağlı akut eozinofilik pnömoni benzeri sendromu tanımlamaktadır. Klinisyenler, trisiklik antidepresanların artış gösteren kullanımını da göz önünde bulundurarak, klomipramine bağlı gelişebilecek hayatı tehdit edici ve tedavi edilebilir akut eozinofilik pnömoni benzeri sendromu akılda tutmalıdır. (Anadolu Psikiyatri Derg 2016; 17(Ek.3):27-30).

First described case of clomipramine-induced acute eosinophilic pneumonia-like syndrome leading to acute respiratory failure

Drugs are well-known causes of eosinophilic lung disease and patients with drug-induced eosinophilic lung disease can have variable clinical presentations. Clinical features may range from asymptomatic eosinophilic infiltrates to acute eosinophilic pneumonia (AEP)-like syndrome leading to acute respiratory failure. This report describes the first case of clomipramine-induced AEP-like syndrome causing acute hypoxemic respiratory failure which was treated successfully. Considering the increasing usage of tricyclic antidepressants, physicians should be aware of this very rare and life-threatening complication of clomipramine. (Anatolian Journal of Psychiatry 2016; 17(Suppl.3):27-30).

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