İzotretinoin Tedavisi Sırasında Galaktore Gelişimi: Yeni Bir Yan Etki mi?

İzotretinoin şiddetli akne tedavisinde kullanılan sentetik bir retinoik asittir. Akne tedavisinde çok etkili olmasına karşın pek çok yan etkileri bulunmaktadır. Akne vulgaris nedeniyle, 40 mg/gün dozunda izotretinoin tedavisi başlanan, 18 yaşındaki kadın bir hastanın, tedavisinin ikinci ayında, sağ memesinden sütlü akıntı gelme şikayeti galaktore olarak değerlendirildi. Başka bir hastalığı ve herhangi bir ilaç kullanma öyküsü yoktu. Etiyolojik nedene yönelik yapılan incelemede laboratuvar ve görüntüleme tetkikleri normal bulundu. Literatürde izoretinoinle ilişkili sadece bir olgu bulunmaktadır. Bu makalede izotretinoin tedavisi sırasında ortaya çıkan hiperprolaktinemisiz galaktore olgusu sunulmaktadır.

Anahtar Kelimeler:

İsotretinoin, galaktore, yan etki, birliktelik

Galactorrhea Development During Isotretinoin Treatment: Is It a Novel Side Effect?

Isotretinoin is a synthetic retinoic acid used in the treatment of resistant acne. Although isotretinoin is very effective in the treatment of acne vulgaris, it has been associated with various adverse effects. An 18-year-old female patient with isotretinoin treatment at the dose of 40 mg/day due to acne vulgaris, the complaint of milk discharge was evaluated as galactorrhea in the second month of treatment. It was learned that she had no other illness and did not take any medication. Laboratory and imaging studies were found to be normal examined for etiological cause. We found only one case reports of galactorrhea associated with the use of isotretinoin in the literature. This article presents a case study of galactorrhea without hyperprolactinemia in a woman being treated with isotretinoin.

Keywords:

Isotretinoin, galactorrhea, side effect, association,

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