Recep ALANLI, Murat Bülent KÜÇÜKAY, Serkan YALÇIN

Obstrüktif Uyku Apne Sendromu Şiddetini Gösteren Kolay ve Pratik Yeni Belirteçler: Ortalama Trombosit Hacmi/Yüksek Dansiteli Lipoprotein ve Eritrosit Dağılım Hacmi/Yüksek Dansiteli Lipoprotein

Amaç: Bu çalışmanın amacı, yeni birer belirteç olan; ortalama trombosit hacmi (MPV)/yüksek dansiteli lipoprotein (HDL) ve eritrosit dağılım hacmi (RDW)/HDL oranları ile obstrüktif uyku apne sendromu (OUAS) varlığı ve şiddeti arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntem: Ocak 2017 ile Mart 2020 arasında polisomnografi yapılan ve sonuçlarına eksiksiz ulaşılabilen 510 hasta ile çalışma yapılmıştır. Tiroid hormon düzeylerini ve uyku düzenini etkileyebilecek ilaç kullanan hastalar çalışma dışı tutulmuştur. OUAS olan ve OUAS olmayan hastaların; yaş, cinsiyet, nötrofil, lenfosit ve trombosit sayısı, ortalama eritrosit hacmi (MCV), MPV, RDW, HDL, monosit/HDL, MPV/HDL ve RDW/HDL oranları karşılaştırıldı. Bulgular: OUAS şiddetiyle; yaş, HDL, RDW, MPV/HDL ve RDW/HDL oranı arasında anlamlı bir ilişki saptanmıştır. OUAS olanlarda kontrol grubuna göre (OUAS olmayan); yaş ve cinsiyet arasında anlamlı bir ilişki saptanmıştır. Sonuç: MPV/HDL ve RDW/HDL oranları, OUAS şiddetini göstermek için yeni birer belirteç olarak kullanılabilir.

Anahtar Kelimeler:

obstrüktif uyku apne sendromu, ortalama trombosit hacmi, eritrosit dağılım hacmi, yüksek dansiteli lipoprotein

New Hematological Indices as Simple and Practical Severity Markers of Obstructive Sleep Apnea Syndrome: Mean Platelet Volume/High Density Lipoprotein and Red-Cell Diameter Width/High Density Lipoprotein Ratio

Purpose: The aim of this study is to analyze correlation between novel markers mean platelet volume (MPV)/high density lipoprotein (HDL) and erythrocyte diameter width (RDW)/HDL ratios, and existence and severity of OSAS. Methods: Patients who had polysomnography test between January 2017 to March 2020 were evaluated and 510 patients whose complete records could be obtained were enrolled. Participants who were using drugs affecting thyroid and sleep order were excluded. Participants were compared for age, gender, monocyte, neutrophil, lymphocyte and platelet counts, mean corpuscular volume (MCV), MPV, RDW, HDL, monocyte/HDL, MPV/HDL and RDW/HDL ratios in OSAS group and control group. Results: There was a significant correlation between severity of OSAS and age, HDL, RDW, MPV/HDL and RDW/HDL ratios. Compared to control group, there were significant differences in age (p=0.005) and HDL (p=0.001) in OSAS group. Conclusion: MPV/HDL and RDW/HDL ratios may be used to predict severity of OSAS, as novel markers.

Keywords:

Obstructive sleep apnea syndrome, Mean platelet volume, red cell diameter width, high density lipoprotein,

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